{"id":"W4318679861","doi":"10.1038/s12276-023-00936-y","title":"BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression","year":2023,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Natural Science Foundation of Hunan Province; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Sunitinib; Melanoma; Bromodomain; BET inhibitor; Cancer research; Pharmacology; BRD4; Medicine; In vivo; Cancer; Chemistry; Epigenetics; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470479,0.0003700264,0.0004740312,0.0003223461,0.0001163095,0.0002611298,0.0001736456,0.0002121512,0.001320897],"category_scores_gemma":[0.00005606444,0.0001287735,0.0003584202,0.0001643103,0.0001251973,0.0001789332,0.0001349306,0.0003787983,0.0002778203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798834,"about_ca_system_score_gemma":0.000289103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004712112,"about_ca_topic_score_gemma":0.002383587,"domain_scores_codex":[0.9999007,0.00001545076,0.000008927413,0.00001456631,0.00002748245,0.00003275033],"domain_scores_gemma":[0.9999676,0.00000415452,0.000008658978,0.000002648822,0.000003230881,0.00001370173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001185344,0.0004224023,0.000709783,0.0001136447,0.00004389104,0.0000883808,0.00001834312,0.0006431791,0.9810642,0.0001498894,0.0003392852,0.01522168],"study_design_scores_gemma":[0.000323012,0.004199099,0.009249694,0.000007551068,0.00005854185,0.0004930148,0.00002802736,0.002119978,0.977656,0.00006847375,0.005785571,0.00001107366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940948,0.002044861,0.0007570744,0.0001349448,0.00004935818,0.00008766757,0.0003496421,0.0001307468,0.002350966],"genre_scores_gemma":[0.9957758,0.0009871933,0.0008554012,0.00005471741,0.000009935278,0.00003298351,0.000401577,0.00001253803,0.001869834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320897,"threshold_uncertainty_score":0.00441885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235095540228268,"score_gpt":0.2910201783504799,"score_spread":0.2786692229481972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}