{"id":"W4318681088","doi":"10.1016/j.celrep.2023.112064","title":"Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; International Microbiome Centre, University of Calgary; Irving Medical Center, Columbia University; National Heart, Lung, and Blood Institute; Alberta Innovates; Canada Foundation for Innovation; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Staphylococcus aureus; Respiratory burst; Innate immune system; Immune system; Metabolite; Microbiology; Biology; Inflammation; Pathogen; Oxidative phosphorylation; Pneumonia; Chemotaxis; Glycolysis; Immunology; Enzyme; Bacteria; Medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168529,0.0002800198,0.0002331596,0.0001216473,0.00006729184,0.0002022318,0.00009417022,0.0002069364,0.0009858622],"category_scores_gemma":[0.0001429647,0.00006861326,0.0001681441,0.00008720187,0.0001362793,0.00009481078,0.0001654676,0.0003840044,0.0001886253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001590179,"about_ca_system_score_gemma":0.0001999707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004888873,"about_ca_topic_score_gemma":0.0007457266,"domain_scores_codex":[0.9998733,0.00002941371,0.00001171034,0.00001385885,0.00002924463,0.000042604],"domain_scores_gemma":[0.9999059,0.0000196996,0.00002319839,0.00001078658,0.00001070232,0.00002958022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003064662,0.00006770801,0.0001247388,0.00002848626,0.000002708561,0.00003097271,0.000009130195,0.00003440752,0.9981198,0.00003707514,0.00004839755,0.001190056],"study_design_scores_gemma":[0.00005699592,0.001378974,0.006124823,0.00001246882,0.000009233197,0.0001376801,0.00002849854,0.000701562,0.9900361,0.00004064386,0.001469321,0.00000369383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960544,0.001203503,0.0007334861,0.0001338033,0.00003461219,0.0000274722,0.0001332129,0.00005656423,0.001623032],"genre_scores_gemma":[0.9975795,0.0004837205,0.0006573988,0.00007691636,0.00001407321,0.0000236692,0.0001748935,0.000007490941,0.0009824547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009858622,"threshold_uncertainty_score":0.003298044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200319709095838,"score_gpt":0.2400711451946426,"score_spread":0.2180679481036842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}