{"id":"W4318682163","doi":"10.1053/j.gastro.2023.01.028","title":"Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis","year":2023,"lang":"en","type":"review","venue":"Gastroenterology","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; European Commission; European Regional Development Fund; Fonds de Recherche du Québec - Santé; National Human Genome Research Institute; HORIZON EUROPE Framework Programme; National Institutes of Health; National Cancer Institute; Eesti Teadusagentuur; Horizon 2020; Canadian Institutes of Health Research","keywords":"Mendelian randomization; Proteome; Computational biology; Acute pancreatitis; Bioinformatics; Biology; Medicine; Genetics; Internal medicine; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003680438,0.0006634111,0.003523323,0.0005126857,0.0001570116,0.00003309443,0.0001438536,0.0009836125,0.00006151211],"category_scores_gemma":[0.0001796018,0.0005118335,0.0004133311,0.0002081597,0.0002828709,0.00007525874,0.0001777871,0.0008991953,0.0001366221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001123354,"about_ca_system_score_gemma":0.0001363748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005370561,"about_ca_topic_score_gemma":0.0001282018,"domain_scores_codex":[0.9967688,0.0005801361,0.0009402148,0.0008335772,0.0002075849,0.0006696577],"domain_scores_gemma":[0.9984694,0.0002137981,0.0004978778,0.0005000762,0.00007926655,0.0002395929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003281374,0.001361996,0.4708882,0.06324705,0.07340633,0.01867155,0.0006259201,8.388921e-7,0.00004725442,0.000164595,0.004193577,0.3641113],"study_design_scores_gemma":[0.1120874,0.02702146,0.1012538,0.07468524,0.3089484,0.03087214,0.00008255085,0.000007022347,0.0002588338,0.001534705,0.3402969,0.002951519],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02787169,0.9591035,0.001393372,0.0005432231,0.0004406944,0.008982903,0.0009617444,0.0004561261,0.0002467672],"genre_scores_gemma":[0.001019884,0.9905396,0.0005468624,0.0001346134,0.0003850664,0.002612944,0.002726284,0.0001200233,0.001914754],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3696344,"threshold_uncertainty_score":0.9997333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03311407136656809,"score_gpt":0.3160732075753871,"score_spread":0.282959136208819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}