{"id":"W4318696263","doi":"10.1126/scisignal.abo4314","title":"The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms","year":2023,"lang":"en","type":"article","venue":"Science Signaling","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Moores Cancer Center, UC San Diego Health; Universität Ulm; National Institutes of Health; University of California, San Diego; Universität Konstanz; Université de Montréal","keywords":"Chemokine receptor; CCR2; CCR1; Cell biology; G protein-coupled receptor; C-C chemokine receptor type 6; CCL21; CC chemokine receptors; XCL2; CCL13; C-C chemokine receptor type 7; G protein-coupled receptor kinase; CXCL14; Chemistry; Biology; Chemokine; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003345225,0.0003668219,0.0003547762,0.0002711916,0.0002968945,0.0009744592,0.0003691819,0.0005918513,0.001526319],"category_scores_gemma":[0.0002248327,0.0002473812,0.0004405307,0.0001554143,0.0004585657,0.0004911651,0.0005595672,0.001299161,0.0005738739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772507,"about_ca_system_score_gemma":0.0005769182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009878014,"about_ca_topic_score_gemma":0.001690262,"domain_scores_codex":[0.9993936,0.00007126448,0.00003783414,0.0001252581,0.000202781,0.0001692114],"domain_scores_gemma":[0.9997795,0.00002027024,0.00005298801,0.00003443894,0.00004239586,0.00007026937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005297019,0.00001516551,0.0002059177,0.00003840895,0.000004200656,0.00006630993,0.00002178022,0.00006958294,0.9967012,0.001181759,0.0001373778,0.00150532],"study_design_scores_gemma":[0.00005291588,0.000257831,0.00685676,0.00002357345,0.00002957278,0.0007624331,0.0001159286,0.003971091,0.9745464,0.0003872747,0.0129709,0.00002524671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640168,0.004563356,0.02159251,0.0009307378,0.0001929507,0.00008350542,0.0005943658,0.0003390936,0.007686698],"genre_scores_gemma":[0.9865117,0.001271394,0.005694464,0.0002569154,0.00002856334,0.00005563222,0.0003404547,0.00005257512,0.005788181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526319,"threshold_uncertainty_score":0.005106091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154461347739831,"score_gpt":0.2666036313162246,"score_spread":0.2511574965422415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}