{"id":"W4318696263","doi":"10.1126/scisignal.abo4314","title":"The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms","year":2023,"lang":"en","type":"article","venue":"Science Signaling","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Moores Cancer Center, UC San Diego Health; Universität Ulm; National Institutes of Health; University of California, San Diego; Universität Konstanz; Université de Montréal","keywords":"Chemokine receptor; CCR2; CCR1; Cell biology; G protein-coupled receptor; C-C chemokine receptor type 6; CCL21; CC chemokine receptors; XCL2; CCL13; C-C chemokine receptor type 7; G protein-coupled receptor kinase; CXCL14; Chemistry; Biology; Chemokine; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001942352,0.0002342312,0.0002709861,0.000180922,0.001405647,0.0002430525,0.0001601586,0.0000814391,0.00009605649],"category_scores_gemma":[0.0005751151,0.0001640259,0.00009645784,0.001899401,0.0004686664,0.0004149986,0.0001466925,0.0002652472,0.00004271283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001254142,"about_ca_system_score_gemma":0.000151443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003840473,"about_ca_topic_score_gemma":0.000008673769,"domain_scores_codex":[0.9975542,0.00003083251,0.0003807096,0.000590045,0.0008336308,0.0006105357],"domain_scores_gemma":[0.9989184,0.0002315609,0.0001525594,0.0003007233,0.0002242262,0.0001725997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005713706,0.00002073969,0.0009682054,0.0000409331,0.00002015783,0.000004760596,0.0008061806,0.00009186348,0.9877543,0.001903831,0.0002828909,0.008049039],"study_design_scores_gemma":[0.0009308138,0.0002178411,0.002557494,0.0003227573,0.0000898525,0.00005015411,0.00220315,0.0155341,0.9680954,0.005385451,0.004287898,0.000325128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860283,0.0002596751,0.008620909,0.003206246,0.000705916,0.0003600513,0.000003857195,0.0002953658,0.0005197124],"genre_scores_gemma":[0.9964569,0.0001714603,0.00201781,0.0001527115,0.0004967594,0.00002739239,0.00003774944,0.00003171157,0.0006074908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0196589,"threshold_uncertainty_score":0.9998944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154461347739831,"score_gpt":0.2666036313162246,"score_spread":0.2511574965422415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}