{"id":"W4318696311","doi":"10.21203/rs.3.rs-1851645/v1","title":"Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging.","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression","keywords":"Hippocampal formation; Neuroscience; Cholinergic; Working memory; Hippocampus; Cholinergic neuron; Psychology; Cognitive aging; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879318,0.000234512,0.0001897545,0.0002733977,0.0001302633,0.0002769774,0.000181767,0.0002213007,0.0007771685],"category_scores_gemma":[0.0002081788,0.0000776075,0.0001447138,0.0001204504,0.0002084345,0.0003049544,0.0003407364,0.0002654663,0.0004660604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396275,"about_ca_system_score_gemma":0.0002320384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546353,"about_ca_topic_score_gemma":0.001101363,"domain_scores_codex":[0.9999541,0.000003771494,0.000004462329,0.000008638472,0.00001996676,0.000009077664],"domain_scores_gemma":[0.9998882,0.000008698679,0.00002815933,0.00001855026,0.00002621556,0.00003024491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000216539,0.00003615901,0.006066986,0.0001557919,0.00002536509,0.0004590603,0.0001651301,0.0001274618,0.9531076,0.001491049,0.0003809282,0.03776791],"study_design_scores_gemma":[0.00005296444,0.0007515348,0.1952048,0.00009437927,0.0001174411,0.003059175,0.0004871913,0.001888623,0.7694188,0.007340623,0.02156326,0.00002131799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791691,0.00736643,0.007491188,0.0001685697,0.00009995712,0.00001646235,0.0004667771,0.0001467685,0.005074901],"genre_scores_gemma":[0.9856431,0.003409409,0.005610074,0.00004121188,0.00003023475,0.00002126317,0.0004571946,0.00001770183,0.004769841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007771685,"threshold_uncertainty_score":0.002599835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1178762142378179,"score_gpt":0.3694656517402659,"score_spread":0.2515894375024481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}