{"id":"W4318701124","doi":"10.32920/21982895.v1","title":"Lysosome remodelling and adaptation during phagocyte activation","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; Toronto Metropolitan University; Natural Sciences and Engineering Research Council of Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Institutes of Health Research; Government of Ontario","keywords":"TFEB; Lysosome; Cell biology; Autophagy; Phagocytosis; Biology; Phagocyte; Cellular adaptation; Antigen presentation; Endocytosis; Immune system; Cell; Immunology; T cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004451263,0.0002860681,0.0004143234,0.0003117509,0.0003419532,0.001172817,0.000230733,0.00089864,0.001677168],"category_scores_gemma":[0.0002686964,0.0001631134,0.0004627355,0.000254068,0.0005938001,0.000800484,0.0007397989,0.000756626,0.001146203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008158071,"about_ca_system_score_gemma":0.0003062667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003367932,"about_ca_topic_score_gemma":0.0003225577,"domain_scores_codex":[0.9997162,0.000038006,0.0000176623,0.00007229584,0.00007612564,0.00007967217],"domain_scores_gemma":[0.9998909,0.00001448801,0.0000260949,0.00001363653,0.00002541197,0.00002945777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006026471,0.00003560112,0.004385788,0.001009187,0.00007557508,0.002457771,0.0006680576,0.001444803,0.9059303,0.01831973,0.004406528,0.06066398],"study_design_scores_gemma":[0.00003364769,0.0002944053,0.03445255,0.0003087035,0.00006626985,0.005748418,0.0005707767,0.0029765,0.780852,0.01557452,0.1590323,0.00009000124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.6825374,0.1670698,0.08545058,0.004691113,0.001643521,0.0002182861,0.002016746,0.00158283,0.05478981],"genre_scores_gemma":[0.9385889,0.02992749,0.01172661,0.000871724,0.0002471777,0.00008936725,0.0009192027,0.0001814712,0.01744804],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001677168,"threshold_uncertainty_score":0.005919158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08277131359421079,"score_gpt":0.3104084458096898,"score_spread":0.227637132215479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}