{"id":"W4318701296","doi":"10.32920/21982919","title":"Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Ontario; Yale University","keywords":"Lysosome; TFEB; Cell biology; Autophagy; Endocytosis; Biology; Mechanistic target of rapamycin; PI3K/AKT/mTOR pathway; Biochemistry; Cell; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203219,0.0002416409,0.0004526199,0.0001439886,0.000110233,0.0003854597,0.0002055954,0.0002955911,0.001583523],"category_scores_gemma":[0.0001128191,0.0001354404,0.0002925341,0.0001422863,0.0002895899,0.0002146772,0.0002174094,0.0006757862,0.0005161768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986003,"about_ca_system_score_gemma":0.0002074168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006826125,"about_ca_topic_score_gemma":0.0005487624,"domain_scores_codex":[0.9998363,0.00001552361,0.00001412945,0.00002965505,0.00004213039,0.00006226148],"domain_scores_gemma":[0.9999218,0.00001987922,0.00001906714,0.000008918631,0.000005979954,0.00002442159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003552696,0.00002579963,0.0001057882,0.00003583916,0.000006194551,0.00005805925,0.000011355,0.00008455729,0.9981773,0.0001293924,0.00007696451,0.0009335119],"study_design_scores_gemma":[0.000009371547,0.00005885146,0.0009829694,0.000001977454,0.000003788651,0.00006725568,0.000008175389,0.0004999477,0.9976386,0.00003171693,0.0006951559,0.00000222323],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9912499,0.001222011,0.003587729,0.000225796,0.00006467394,0.00002847765,0.0006945888,0.0001763424,0.002750448],"genre_scores_gemma":[0.9946671,0.0005022437,0.00160542,0.00006548828,0.00001007882,0.00002916297,0.0004388743,0.00004514782,0.002636456],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001583523,"threshold_uncertainty_score":0.005297363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03581083531569235,"score_gpt":0.294860561796381,"score_spread":0.2590497264806887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}