{"id":"W4318701304","doi":"10.32920/21982916.v1","title":"Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Toronto Metropolitan University; University of Toronto","funders":"Canada Research Chairs; Government of Ontario","keywords":"Lysosome; Cell biology; Endosome; Phagosome; Lipid bilayer fusion; Biology; Chemistry; Biochemistry; Phagocytosis; Intracellular; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599863,0.0002896302,0.0004390573,0.0001285915,0.0001165692,0.0002655104,0.0003247481,0.0003470747,0.0009089235],"category_scores_gemma":[0.0002171579,0.000118393,0.0003205234,0.0001098158,0.0001638498,0.0002700434,0.0002304026,0.000621174,0.0002262009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002205641,"about_ca_system_score_gemma":0.0002054826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006280851,"about_ca_topic_score_gemma":0.0006683991,"domain_scores_codex":[0.9997945,0.00001934087,0.00002629498,0.00004487038,0.00005026984,0.00006464533],"domain_scores_gemma":[0.999858,0.0000286322,0.00004325317,0.00001552368,0.00002240167,0.00003214003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004873059,0.00007631631,0.000125486,0.00007840616,0.00001255536,0.0000577491,0.00002230641,0.00009166198,0.9968783,0.0001069062,0.0001442773,0.001918628],"study_design_scores_gemma":[0.00001170212,0.0001798802,0.0009275511,0.000003294552,0.000008058957,0.00004730666,0.000009336837,0.0007141094,0.9968113,0.00002268816,0.001261219,0.000003513704],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.991949,0.002205431,0.003113423,0.0001459133,0.00008567605,0.00005033941,0.0004309811,0.000165547,0.001853629],"genre_scores_gemma":[0.9957848,0.0006108979,0.001462357,0.00007627442,0.00001154563,0.00005174775,0.0004605276,0.00002662824,0.00151512],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0009089235,"threshold_uncertainty_score":0.003040612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02117314478162978,"score_gpt":0.2355963639825119,"score_spread":0.2144232192008821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}