{"id":"W4318705146","doi":"10.32920/21982901.v1","title":"The Lysosome Signaling Platform: Adapting With the Times","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Lysosome; Autophagy; Cell biology; mTORC1; Endocytosis; ATG16L1; Cellular adaptation; TFEB; Biology; Organelle; Inflammasome; Signal transduction; Inflammation; Cell; Biochemistry; PI3K/AKT/mTOR pathway; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007843804,0.0007086053,0.0005820417,0.0005212012,0.0007888862,0.003847843,0.0004254624,0.002192967,0.005663817],"category_scores_gemma":[0.0007780371,0.0002859323,0.0005979352,0.0004577896,0.001337982,0.004259656,0.001711721,0.003059601,0.005442276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001166188,"about_ca_system_score_gemma":0.0009771832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003686345,"about_ca_topic_score_gemma":0.0003513068,"domain_scores_codex":[0.999607,0.00007540307,0.00002497033,0.0000845784,0.0001461718,0.0000617936],"domain_scores_gemma":[0.9998037,0.00003301243,0.00002733702,0.00002900889,0.00004718623,0.00005974172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004382505,0.00004568351,0.001178048,0.002488111,0.0001828461,0.002798875,0.001424085,0.00304017,0.1240114,0.4352867,0.1138959,0.31521],"study_design_scores_gemma":[0.00002067343,0.00007472958,0.0009273752,0.0003774037,0.00004064434,0.001697741,0.0004203503,0.001253142,0.03520951,0.08101781,0.8789139,0.00004667715],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.04011198,0.5887765,0.1218865,0.07921286,0.0309076,0.0001552482,0.001151873,0.003184955,0.1346126],"genre_scores_gemma":[0.33021,0.3737306,0.06012102,0.01827011,0.01287205,0.0002584223,0.001449115,0.001103541,0.2019852],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005663817,"threshold_uncertainty_score":0.01894736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04726697997185854,"score_gpt":0.2947391284385271,"score_spread":0.2474721484666686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}