{"id":"W4318707901","doi":"10.3389/fonc.2022.1028825","title":"End-of-neoadjuvant treatment circulating microRNAs and HER2-positive breast cancer patient prognosis: An exploratory analysis from NeoALTTO","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministero della Salute; Novartis; GlaxoSmithKline","keywords":"Medicine; Oncology; Trastuzumab; Breast cancer; Internal medicine; Proportional hazards model; Hazard ratio; Neoadjuvant therapy; microRNA; Multivariate analysis; Confidence interval; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128308,0.0001822433,0.0003812965,0.0002429011,0.0000528238,0.00001040288,0.00009597142,0.0002026697,0.00002005109],"category_scores_gemma":[0.00001390326,0.000180873,0.0001064304,0.0004008103,0.0001356673,0.00001000976,0.00008307961,0.00005598058,0.000001247815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002478567,"about_ca_system_score_gemma":0.0001995032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005986215,"about_ca_topic_score_gemma":0.0010403,"domain_scores_codex":[0.9985669,0.0002442082,0.0003322671,0.0005019041,0.00009534053,0.0002593654],"domain_scores_gemma":[0.9993469,0.00002003673,0.0002010285,0.0002464833,0.000077137,0.0001084354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003650123,0.0004140016,0.5330259,0.00001724496,0.001395834,0.00005896881,0.002593717,0.00238602,0.2958913,0.000003849862,0.0009087333,0.1629393],"study_design_scores_gemma":[0.002114652,0.001259348,0.8616754,0.00007264112,0.0009172254,0.00001176193,0.004873637,0.005999034,0.1189118,0.0001371623,0.00351343,0.0005139298],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955354,0.002611983,0.0005301068,0.0001602366,0.0002663863,0.0003351118,0.0005118861,0.00001749824,0.00003133066],"genre_scores_gemma":[0.9958894,0.0005885112,0.002217895,0.00006743257,0.0001050236,0.0001936633,0.0009037188,0.00002298709,0.00001131541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3286494,"threshold_uncertainty_score":0.7375785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151613694950658,"score_gpt":0.2758597328626889,"score_spread":0.2643435959131823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}