{"id":"W4318711978","doi":"10.32920/21982883.v1","title":"Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Centre for Addiction and Mental Health; Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Signal transducing adaptor protein; Cell biology; Phosphatase; Biology; Phosphatidylinositol; Organelle; Function (biology); Ubiquitin; Phosphorylation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442724,0.0003731981,0.0003408822,0.0002438456,0.00027584,0.0004755183,0.0002444318,0.0003812034,0.001414985],"category_scores_gemma":[0.0001889496,0.0002355123,0.0003502097,0.0001374722,0.0001408358,0.000261932,0.0004409254,0.0003569792,0.001053999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006090559,"about_ca_system_score_gemma":0.0002058075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009783957,"about_ca_topic_score_gemma":0.0009420558,"domain_scores_codex":[0.9997808,0.00002446822,0.00002089336,0.00005070422,0.00006140549,0.00006174255],"domain_scores_gemma":[0.9998344,0.00001525708,0.000057074,0.00002205681,0.0000340516,0.00003704418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003537764,0.000005148371,0.0006121019,0.0000238116,0.000006370323,0.00007419968,0.00001182171,0.00003666319,0.9979177,0.000150092,0.00005987079,0.001066789],"study_design_scores_gemma":[0.000007275427,0.00006643526,0.02183466,0.000006167254,0.00001293344,0.0009104135,0.00003391848,0.001223579,0.9696299,0.0001115517,0.006155618,0.000007538427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915257,0.001553336,0.005207047,0.00007427599,0.000018244,0.00001706239,0.0005461929,0.0001959799,0.0008623071],"genre_scores_gemma":[0.9915331,0.0005048729,0.003817436,0.0000240627,0.000006138683,0.00002308405,0.001750791,0.00004704414,0.002293383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414985,"threshold_uncertainty_score":0.004733622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03491785719953735,"score_gpt":0.2648730552681746,"score_spread":0.2299551980686372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}