{"id":"W4318715876","doi":"10.32920/21982886","title":"mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Massachusetts Institute of Technology","keywords":"Lysosome; Cell biology; PI3K/AKT/mTOR pathway; Autophagy; Endosome; Antigen presentation; Biology; Protein kinase B; Phagosome; Chemistry; Signal transduction; Immunology; T cell; Phagocytosis; Immune system; Apoptosis; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170455,0.0002218397,0.0002554544,0.0002574732,0.0002583715,0.0005478389,0.0001408423,0.0003132955,0.001242595],"category_scores_gemma":[0.0001320556,0.0001533312,0.0001965243,0.0002094343,0.0002844868,0.00026049,0.0003434969,0.00028221,0.0009627009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004527225,"about_ca_system_score_gemma":0.0002815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005404866,"about_ca_topic_score_gemma":0.000661827,"domain_scores_codex":[0.9998562,0.00001843124,0.000008530118,0.00003586957,0.00004067393,0.00004023907],"domain_scores_gemma":[0.9999446,0.000004456971,0.00001598351,0.000005275126,0.000009320288,0.0000204385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001955558,0.00001338219,0.0004814781,0.0000410052,0.000005349067,0.0001466004,0.00002250232,0.0002205693,0.9953177,0.0008197575,0.0002434135,0.00249276],"study_design_scores_gemma":[0.00003919311,0.0001020789,0.01614187,0.00000959616,0.00001381205,0.0004420454,0.00008262036,0.00461735,0.9682838,0.001149322,0.009105652,0.00001252237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818745,0.002807374,0.005128549,0.0004192843,0.00009490512,0.00002555053,0.0006615467,0.0002487377,0.008739674],"genre_scores_gemma":[0.9897635,0.00105777,0.00220199,0.00007542069,0.00003075328,0.00002731452,0.0005936703,0.00008558143,0.006163938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242595,"threshold_uncertainty_score":0.004156947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413265081632529,"score_gpt":0.2532708494803758,"score_spread":0.2391381986640505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}