{"id":"W4318716542","doi":"10.32920/21982928.v1","title":"Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Toronto Metropolitan University","funders":"Uppsala Multidisciplinary Center for Advanced Computational Science; Canadian Institutes of Health Research; Science for Life Laboratory; Hospital for Sick Children; National Institutes of Health; Vetenskapsrådet; Government of Ontario; Canada Research Chairs; Cancerfonden; Knut och Alice Wallenbergs Stiftelse","keywords":"TFEB; Lysosome; Cell biology; Autophagy; Biology; mTORC1; ATG16L1; Endosome; PI3K/AKT/mTOR pathway; Phagocytosis; Endocytosis; Antigen presentation; Signal transduction; Biochemistry; Cell; Immune system; Intracellular; Immunology; T cell; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171246,0.0002463726,0.0003295245,0.0001897021,0.00009390122,0.0003532127,0.0001018342,0.000244963,0.001557611],"category_scores_gemma":[0.0001538709,0.0001211265,0.0002870803,0.0001186641,0.000190753,0.0001907057,0.0002596368,0.0004447208,0.0005865406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224554,"about_ca_system_score_gemma":0.0001381234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001546347,"about_ca_topic_score_gemma":0.0002213826,"domain_scores_codex":[0.9998218,0.0000279062,0.00001801936,0.00003449509,0.00003464041,0.00006314371],"domain_scores_gemma":[0.9998546,0.00002609669,0.00004210433,0.00001359517,0.00001675092,0.00004685432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001905492,0.000018331,0.0001130124,0.0000242812,0.000001612913,0.0000335264,0.000007825396,0.000015015,0.9990169,0.0000225364,0.00002914761,0.0005272394],"study_design_scores_gemma":[0.00002104434,0.0005044218,0.02489959,0.00001459745,0.00001357056,0.000232713,0.00006133696,0.0007754687,0.9713293,0.00006057132,0.002078406,0.000008971909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941787,0.002254104,0.001537116,0.0001360782,0.00005851646,0.00002097689,0.0004056863,0.00008572005,0.001323099],"genre_scores_gemma":[0.9962392,0.000687301,0.0007966317,0.00009320819,0.00002467196,0.00003881285,0.0004794509,0.00002795795,0.001612762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557611,"threshold_uncertainty_score":0.005210757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02350142846977527,"score_gpt":0.2641182169749588,"score_spread":0.2406167885051835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}