{"id":"W4318754183","doi":"10.1002/ardp.202200610","title":"Development of a multigram synthesis of the bradykinin receptor 2 agonist FR‐190997 and analogs thereof","year":2023,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"University of Patras","keywords":"Chemistry; Agonist; Bradykinin; Combinatorial chemistry; In vivo; Repurposing; In vitro; Pharmacology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422481,0.0001737933,0.0003561166,0.000137854,0.0001405075,0.000009653908,0.0001693627,0.00004597276,0.0001727826],"category_scores_gemma":[0.0001660109,0.0001228755,0.0001400361,0.0003870017,0.0002566491,0.00004805264,0.0001378144,0.0001141365,0.00003225899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000165737,"about_ca_system_score_gemma":0.0001799291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009680121,"about_ca_topic_score_gemma":0.00004571321,"domain_scores_codex":[0.9986185,0.00007055842,0.0004705469,0.0002495346,0.0003235357,0.000267298],"domain_scores_gemma":[0.9989743,0.0003600967,0.0001847697,0.0003059118,0.00005753717,0.000117356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004698183,0.0006240459,0.2222271,0.0009008819,0.001155717,0.00001594196,0.02732611,0.00002122355,0.3056409,0.001100613,0.01150289,0.4290148],"study_design_scores_gemma":[0.001578207,0.0000521471,0.5757037,0.0004125678,0.0002262128,0.00001716913,0.0006875511,0.001135365,0.3885947,0.0003101478,0.03105445,0.0002277495],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962344,0.0004774138,0.0000379977,0.0008338187,0.0001537267,0.0003661947,0.00004589035,0.00007397643,0.001776556],"genre_scores_gemma":[0.9964191,0.0001648716,0.002426557,0.000174796,0.00006943873,0.00003072826,0.00002925505,0.00003031367,0.0006549874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4287871,"threshold_uncertainty_score":0.5010719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03003949784637767,"score_gpt":0.2886266408635281,"score_spread":0.2585871430171505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}