{"id":"W4318762665","doi":"10.1016/s2468-1253(22)00427-7","title":"Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Janssen Scientific Affairs","keywords":"Golimumab; Medicine; Ulcerative colitis; Internal medicine; Randomization; Randomized controlled trial; Clinical endpoint; Clinical trial; Surgery; Gastroenterology; Adalimumab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001560595,0.00184697,0.003753361,0.0004574077,0.0003673993,0.001275577,0.0009432183,0.002347106,0.00786154],"category_scores_gemma":[0.001479553,0.0007866631,0.002025466,0.0004327965,0.001066039,0.001316456,0.0004731124,0.003588245,0.001303025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006869163,"about_ca_system_score_gemma":0.0006972114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006678184,"about_ca_topic_score_gemma":0.001559086,"domain_scores_codex":[0.9994893,0.0002455927,0.00002894713,0.00008791604,0.00004199981,0.0001062618],"domain_scores_gemma":[0.9993141,0.0002634582,0.0001372607,0.00004451491,0.00004299086,0.0001976727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9782354,0.002123812,0.0001871523,0.001164655,0.0009977861,0.00004315614,0.00003575396,0.0001907164,0.002296557,0.00009971154,0.0007681394,0.01385718],"study_design_scores_gemma":[0.9706843,0.0273519,0.0006662989,0.0000468403,0.0003532752,0.00002947657,0.0000161893,0.0001474083,0.0001519394,0.0001013954,0.0004413238,0.000009696464],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637817,0.02360331,0.0009280971,0.002042823,0.002132372,0.003116617,0.001452706,0.0002456286,0.002696888],"genre_scores_gemma":[0.9756728,0.009180652,0.002231566,0.002297796,0.0009712254,0.004197733,0.001167557,0.00003821291,0.004242498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00786154,"threshold_uncertainty_score":0.02629942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912961698413379,"score_gpt":0.2966711830630394,"score_spread":0.2675415660789056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}