{"id":"W4318762665","doi":"10.1016/s2468-1253(22)00427-7","title":"Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial","year":2023,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Janssen Scientific Affairs","keywords":"Golimumab; Medicine; Ulcerative colitis; Internal medicine; Randomization; Randomized controlled trial; Clinical endpoint; Clinical trial; Surgery; Gastroenterology; Adalimumab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008319221,0.0006596821,0.001682631,0.0003346312,0.0002178062,0.00004454499,0.000820005,0.0004759436,0.00008621443],"category_scores_gemma":[0.00009647947,0.0004766593,0.0003358062,0.0003538183,0.0008331629,0.00003725905,0.0001559804,0.0004608452,0.00001424239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783512,"about_ca_system_score_gemma":0.0005286956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000544038,"about_ca_topic_score_gemma":0.002067178,"domain_scores_codex":[0.9945889,0.001619643,0.001182352,0.0009643801,0.0003918152,0.001252897],"domain_scores_gemma":[0.9973596,0.0002266088,0.0008162866,0.001029952,0.0003963859,0.0001711771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9834432,0.001436706,0.01028453,0.00002467654,0.001096143,0.0001290815,0.0004963464,0.0004372799,0.0001631303,0.0001163252,0.001296173,0.001076386],"study_design_scores_gemma":[0.9724228,0.01630419,0.007544688,0.00002278604,0.0001426113,0.00001891967,0.0001095783,0.001121536,0.001104225,0.00005247972,0.0008187264,0.0003374563],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902892,0.00008841021,0.0003954904,0.0006852474,0.0009519107,0.007242093,0.000166185,0.00007983731,0.0001016536],"genre_scores_gemma":[0.9947463,0.000131437,0.00005006392,0.0008345012,0.000407967,0.002849478,0.0007327661,0.00009919924,0.0001483169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01486749,"threshold_uncertainty_score":0.9997685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912961698413379,"score_gpt":0.2966711830630394,"score_spread":0.2675415660789056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}