{"id":"W4318764020","doi":"10.1038/s41584-023-00910-y","title":"ERAP1 and the return of the UPR in ankylosing spondylitis","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Ankylosing spondylitis; Medicine; Unfolded protein response; Endoplasmic reticulum; Spondylitis; HLA-B27; Disease; Immunology; Bioinformatics; Human leukocyte antigen; Genetics; Internal medicine; Biology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001019315,0.000465583,0.005369253,0.000179164,0.0001132367,0.000010243,0.000269389,0.0008365221,0.00004776972],"category_scores_gemma":[0.001212289,0.0001962815,0.0008987132,0.0009443577,0.0004988314,0.00002156466,0.0002627748,0.001667015,0.00002604609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008164873,"about_ca_system_score_gemma":0.0001495624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008858261,"about_ca_topic_score_gemma":0.0002207121,"domain_scores_codex":[0.9966656,0.0009389686,0.001362839,0.0004655229,0.0002119438,0.0003551334],"domain_scores_gemma":[0.9973863,0.0009185235,0.0008018182,0.0007859572,0.00005594083,0.00005144691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006948716,0.00004786808,0.0009058604,0.04719527,0.0004955163,0.00009487101,0.0001594935,2.668996e-9,2.73062e-8,0.004345259,0.002437972,0.9442484],"study_design_scores_gemma":[0.001682911,0.0000341557,0.0001276333,0.08273092,0.0009554693,0.002312094,0.00001743234,6.385614e-7,1.1269e-7,0.0001680016,0.9118438,0.0001268394],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001129144,0.9946564,2.26612e-7,0.0007200729,0.0006862413,0.00329386,0.00009580493,0.00001946543,0.0004149584],"genre_scores_gemma":[0.00007388488,0.9989727,0.00003589431,0.0001580657,0.00003413836,0.000317195,0.00007398018,0.00005197779,0.0002821584],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9441215,"threshold_uncertainty_score":0.8004128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03865866281636752,"score_gpt":0.3627348578349786,"score_spread":0.3240761950186111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}