{"id":"W4318764131","doi":"10.1101/2023.01.29.526107","title":"LTK and ALK regulate neuronal polarity and cortical migration by modulating IGF1R activity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Canadian Institutes of Health Research; Oregon Health and Science University","keywords":"Biology; Axon guidance; Axon; Neuroscience; Phenotype; Cell biology; Tyrosine kinase; Embryonic stem cell; Kinase; Cell polarity; Dendrite (mathematics); Signal transduction; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008712608,0.0001682936,0.0001253947,0.0001606927,0.0001343068,0.0003610298,0.0001407398,0.0001927109,0.001666146],"category_scores_gemma":[0.00006780393,0.00008913684,0.0001071243,0.0000727944,0.0001981513,0.000135202,0.0001817431,0.0003041931,0.0005503605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000402457,"about_ca_system_score_gemma":0.0001547405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009010672,"about_ca_topic_score_gemma":0.001727389,"domain_scores_codex":[0.9999501,0.000005321002,0.000003635605,0.000009468359,0.00001342797,0.00001815903],"domain_scores_gemma":[0.9999599,0.000004001296,0.000015387,0.0000030068,0.000004125934,0.00001353252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971633,0.00001207525,0.0004652281,0.00002021103,0.000003389865,0.00004054037,0.000008392991,0.0001137392,0.9971607,0.0001901999,0.0001185717,0.001669679],"study_design_scores_gemma":[0.00006272034,0.0001427443,0.02438455,0.00001223377,0.0000202622,0.000175561,0.00009000061,0.002958141,0.9668126,0.0002626169,0.005067501,0.00001115429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889937,0.002325193,0.003155146,0.0003463019,0.00004205255,0.00001403665,0.0007571044,0.000123205,0.004243169],"genre_scores_gemma":[0.9925395,0.0007150857,0.001427712,0.00008302835,0.000009994842,0.00001874927,0.000361852,0.00003061121,0.004813436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666146,"threshold_uncertainty_score":0.005573869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327446434778024,"score_gpt":0.2618350636271354,"score_spread":0.2385605992793551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}