{"id":"W4318773532","doi":"10.1016/j.jsps.2023.01.011","title":"Prediction of herb-drug interactions involving consumption of furanocoumarin-mixtures and cytochrome P450 1A2-mediated caffeine metabolism inhibition in humans","year":2023,"lang":"en","type":"article","venue":"Saudi Pharmaceutical Journal","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"King Abdullah International Medical Research Center; Simon Fraser University","keywords":"Physiologically based pharmacokinetic modelling; Pharmacology; Drug; Caffeine; In vivo; Drug interaction; Furanocoumarin; Chemistry; Drug metabolism; Cytochrome P450; Pharmacokinetics; Medicine; Biology; Metabolism; Biochemistry; Biotechnology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000818026,0.0008237365,0.0006638802,0.0004410105,0.0001278923,0.0005808687,0.0003692229,0.00071754,0.0007938683],"category_scores_gemma":[0.002183082,0.0003574636,0.0008851688,0.0002490848,0.0001634833,0.0002724934,0.0003035305,0.0005754204,0.0002723103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005456458,"about_ca_system_score_gemma":0.0005591814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007130497,"about_ca_topic_score_gemma":0.004340892,"domain_scores_codex":[0.9997213,0.0001093128,0.00001450747,0.00009116708,0.00004008187,0.00002356105],"domain_scores_gemma":[0.9989735,0.0007445581,0.0001510142,0.00003411442,0.00005823803,0.00003864114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0008635847,0.0003610837,0.05693015,0.0001319875,0.0003494268,0.0003190857,0.00004714093,0.8987971,0.005658983,0.0003206411,0.0006571899,0.03556361],"study_design_scores_gemma":[0.0000189919,0.0003025723,0.01174992,0.000008095687,0.00009095739,0.0001191606,0.00001239774,0.9847822,0.002131268,0.0003858408,0.0003864246,0.00001217866],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9143623,0.001416322,0.08049252,0.0003681618,0.00002292422,0.0000977195,0.000970966,0.0004360443,0.001833133],"genre_scores_gemma":[0.9917766,0.0002566686,0.006591513,0.00005766831,0.000008178161,0.00003824565,0.0004774148,0.00001900153,0.0007747533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007130497,"threshold_uncertainty_score":0.01417798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1461295095450139,"score_gpt":0.4292556543516228,"score_spread":0.2831261448066089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}