{"id":"W4318774986","doi":"10.22541/au.167526201.12576513/v1","title":"Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene isoform; Alternative splicing; Transcription factor; Biology; Computational biology; Hepatocyte nuclear factor 4; Hepatocyte nuclear factors; RNA splicing; Regulation of gene expression; Nuclear receptor; Function (biology); Gene; Genetics; Locus (genetics); Cell biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002391461,0.0003168665,0.0002614235,0.001355705,0.000327066,0.0007803657,0.0001680952,0.0002838739,0.002865541],"category_scores_gemma":[0.0003069151,0.0001689236,0.0003509533,0.001254164,0.000218116,0.000652884,0.0004546668,0.0003853501,0.001271288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004151933,"about_ca_system_score_gemma":0.0002369814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008234469,"about_ca_topic_score_gemma":0.0006996981,"domain_scores_codex":[0.9997925,0.00003678276,0.00001417404,0.00004674461,0.00006844984,0.00004137352],"domain_scores_gemma":[0.9999149,0.00001909785,0.00002219073,0.000007074338,0.00002254343,0.00001426932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001223366,0.00008096429,0.03216505,0.003151429,0.0004197151,0.004889423,0.001478607,0.000579462,0.4454613,0.01478591,0.01120252,0.4845622],"study_design_scores_gemma":[0.00005131416,0.0002202083,0.1859552,0.0007092246,0.0004841713,0.01802317,0.001489743,0.003700013,0.1407433,0.01422222,0.6342996,0.0001018284],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4822733,0.444089,0.02340993,0.002664499,0.0004904618,0.00004990545,0.003549441,0.0005372051,0.04293623],"genre_scores_gemma":[0.674516,0.2549456,0.01435421,0.0005643587,0.0006932511,0.00009632883,0.006615954,0.0002175164,0.04799682],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002865541,"threshold_uncertainty_score":0.009586215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0479009630712979,"score_gpt":0.2670699370906522,"score_spread":0.2191689740193543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}