{"id":"W4318776762","doi":"10.3390/cancers15030905","title":"SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa; Université de Montréal; Centre Hospitalier Universitaire de Sherbrooke; McGill University Health Centre; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"SOCS3; Suppressor of cytokine signaling 1; Hepatocellular carcinoma; Cancer research; STAT3; Biology; Downregulation and upregulation; Oxidative stress; Medicine; Signal transduction; Internal medicine; Gene; Cancer; Endocrinology; Cell biology; Suppressor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798804,0.0003146797,0.0002858194,0.0004021263,0.0001470057,0.000268206,0.00008057198,0.0001088428,0.002314805],"category_scores_gemma":[0.0001554596,0.0001112142,0.0004237813,0.000241919,0.0002237619,0.0001587865,0.000232176,0.0003057967,0.0002942878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003940446,"about_ca_system_score_gemma":0.0003822482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002054642,"about_ca_topic_score_gemma":0.003635639,"domain_scores_codex":[0.9998436,0.00001845739,0.00001664138,0.00003035608,0.00002784526,0.00006294763],"domain_scores_gemma":[0.9998329,0.00001350538,0.00005280418,0.00001686613,0.00002154258,0.00006232103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001291086,0.00004520548,0.01271235,0.0002983556,0.00008649717,0.0001916732,0.00004427532,0.0004138266,0.9747035,0.000209939,0.0005700145,0.009433419],"study_design_scores_gemma":[0.0001599836,0.001154552,0.2581397,0.00005233135,0.0002521669,0.001873237,0.000197391,0.004615413,0.7201447,0.0004574133,0.01291964,0.00003348552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922175,0.002581417,0.001315763,0.0001159515,0.00003369568,0.00002169922,0.002283357,0.0002015588,0.00122912],"genre_scores_gemma":[0.9969952,0.000532086,0.0004163524,0.00004427933,0.000006081105,0.00002154336,0.001431374,0.00001493834,0.0005381219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002314805,"threshold_uncertainty_score":0.007743776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922597363168228,"score_gpt":0.2785867270858895,"score_spread":0.2393607534542072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}