{"id":"W4318776762","doi":"10.3390/cancers15030905","title":"SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa; Université de Montréal; Centre Hospitalier Universitaire de Sherbrooke; McGill University Health Centre; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"SOCS3; Suppressor of cytokine signaling 1; Hepatocellular carcinoma; Cancer research; STAT3; Biology; Downregulation and upregulation; Oxidative stress; Medicine; Signal transduction; Internal medicine; Gene; Cancer; Endocrinology; Cell biology; Suppressor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178141,0.0001106078,0.0001410628,0.0001551895,0.000155632,0.00002226232,0.0000346738,0.00007070731,0.0001245055],"category_scores_gemma":[0.00007503795,0.0001030448,0.00005083572,0.0003021402,0.00004977605,0.0001275715,0.00002354784,0.0001789134,0.00004587725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005463616,"about_ca_system_score_gemma":0.0002684084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007864598,"about_ca_topic_score_gemma":0.00002025442,"domain_scores_codex":[0.9991774,0.00001728871,0.0001629147,0.0002543916,0.0001922648,0.0001957423],"domain_scores_gemma":[0.9995708,0.00003192799,0.00006940943,0.0001516258,0.00008780204,0.0000884188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005694797,0.00002076651,0.02165509,0.0000971167,0.00002560579,0.00001663511,0.001022658,0.000139346,0.9635506,0.00008324596,0.001135116,0.01219685],"study_design_scores_gemma":[0.00119424,0.000538407,0.04066179,0.0001892898,0.0001082487,0.0001112388,0.001359729,0.02518873,0.9250463,0.0004704154,0.004841937,0.0002897137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966436,0.0001312744,0.00105948,0.0006283951,0.0003854901,0.0003210768,0.000008931996,0.0001430297,0.0006787164],"genre_scores_gemma":[0.999106,0.00005975496,0.00006125385,0.0001150862,0.0002466263,0.00005238105,0.00005932563,0.00002129749,0.0002783102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03850436,"threshold_uncertainty_score":0.4202046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922597363168228,"score_gpt":0.2785867270858895,"score_spread":0.2393607534542072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}