{"id":"W4318779486","doi":"10.1016/j.bbih.2023.100592","title":"Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients","year":2023,"lang":"en","type":"article","venue":"Brain Behavior & Immunity - Health","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Center for Medical Innovation, Swanson School of Engineering, University of Pittsburgh; Center for Innovative Medicine; European Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alzheimerfonden; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Riksbankens Jubileumsfond; Demensförbundet; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Stockholms Läns Landsting; NordForsk; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Karolinska Institutet; Fondation pour la Recherche Médicale; Hjärnfonden","keywords":"Allostatic load; Internal medicine; Memory clinic; Medicine; Dementia; Effects of sleep deprivation on cognitive performance; Cognition; Alzheimer's disease; Cognitive decline; Glycated hemoglobin; Episodic memory; Psychology; Endocrinology; Oncology; Clinical psychology; Disease; Gerontology; Diabetes mellitus; Psychiatry; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009140326,0.0003819001,0.0004881127,0.0008730582,0.0007043993,0.0007977913,0.0003898474,0.0006198005,0.0007728887],"category_scores_gemma":[0.001915039,0.0003771982,0.0004103309,0.001112021,0.0002110611,0.0005235306,0.0004178351,0.0008609617,0.0003854581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000324,"about_ca_system_score_gemma":0.0003098102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008067491,"about_ca_topic_score_gemma":0.00839314,"domain_scores_codex":[0.9995983,0.0001221034,0.00003464925,0.0001022422,0.00006952293,0.00007321869],"domain_scores_gemma":[0.9988441,0.0001450656,0.0003630646,0.0001219398,0.0002392298,0.0002865654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000223247,0.00008843547,0.9984881,0.000005361886,0.00007213132,0.00006409389,0.0001362567,0.00001327252,0.0002065044,0.000006768149,0.00006685653,0.0006289414],"study_design_scores_gemma":[0.00001649513,0.0001681058,0.9993014,0.000002946966,0.00003496138,0.0001167296,0.000142361,0.0000619913,0.00002496048,0.00001297452,0.0001137335,0.000003352836],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994584,0.0001411956,0.00003191637,0.00001850715,0.000003425232,0.000005762399,0.0001977524,0.000002411387,0.0001405371],"genre_scores_gemma":[0.9992723,0.00008077232,0.00005209287,0.000026847,0.000007361929,0.000009427354,0.0004073874,0.000001517837,0.0001424009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008067491,"threshold_uncertainty_score":0.01604104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07953694725772008,"score_gpt":0.4062010888476508,"score_spread":0.3266641415899307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}