{"id":"W4318815491","doi":"10.3390/cells12030467","title":"Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ—A Pilot Study","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Juvenile Diabetes Research Foundation United Kingdom","keywords":"Peripheral blood mononuclear cell; Ionomycin; Cytokine; Endocrinology; Internal medicine; Medicine; Immunology; Interleukin; Biology; Stimulation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009700006,0.0002705459,0.0005491911,0.00007977188,0.00005597952,0.00002466832,0.00006747628,0.00005086452,0.0002883886],"category_scores_gemma":[0.00002502195,0.0002018584,0.00003263257,0.0002157223,0.0001944774,0.00007793015,0.000113626,0.00009382665,0.00001588138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001297421,"about_ca_system_score_gemma":0.00003295498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004509768,"about_ca_topic_score_gemma":0.000002611009,"domain_scores_codex":[0.9984968,0.00007149496,0.0003094976,0.0005140839,0.0003221386,0.000286012],"domain_scores_gemma":[0.999016,0.00009365211,0.0001557982,0.00035883,0.0001687009,0.0002070205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001203408,0.003678094,0.8636904,0.0004504423,0.0006534982,0.00007203581,0.001126932,0.000003012755,0.126316,0.00000186957,0.000323508,0.002480746],"study_design_scores_gemma":[0.004729648,0.01121638,0.9526937,0.0002105712,0.000780159,3.389428e-7,0.0001568926,0.00001663937,0.02989534,0.00003639988,0.00007000343,0.0001939174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974927,0.0004790077,1.458179e-7,0.00003089592,0.0001285566,0.0009344835,0.0007531156,0.00002945853,0.000151635],"genre_scores_gemma":[0.9982808,0.00007801845,0.0001338391,0.00003382663,0.00004290627,0.00001349184,0.00002837995,0.00005448766,0.001334255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09642066,"threshold_uncertainty_score":0.8231545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904536065774752,"score_gpt":0.2303086851450814,"score_spread":0.2112633244873339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}