{"id":"W4318815491","doi":"10.3390/cells12030467","title":"Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ—A Pilot Study","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Juvenile Diabetes Research Foundation United Kingdom","keywords":"Peripheral blood mononuclear cell; Ionomycin; Cytokine; Endocrinology; Internal medicine; Medicine; Immunology; Interleukin; Biology; Stimulation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003164396,0.0003718793,0.0004010153,0.0003770476,0.0003809645,0.0004833185,0.0001514274,0.0003034324,0.003112639],"category_scores_gemma":[0.000474969,0.0002096095,0.0003231954,0.0003679074,0.0001716293,0.0002096123,0.0002692811,0.0003868524,0.0005046189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009628174,"about_ca_system_score_gemma":0.0001088154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004727805,"about_ca_topic_score_gemma":0.0005489403,"domain_scores_codex":[0.9997827,0.00004920499,0.00002343327,0.00007164673,0.00003334097,0.00003954588],"domain_scores_gemma":[0.9996805,0.00007607474,0.00009465352,0.00003250467,0.00004380177,0.00007240869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005780053,0.0009344128,0.9307168,0.0002666175,0.0002151215,0.001491532,0.0005788865,0.00005455759,0.04062362,0.0000380995,0.0002479264,0.01905227],"study_design_scores_gemma":[0.0001834138,0.004877031,0.9823449,0.00003353127,0.0002142687,0.00609388,0.0006275732,0.0001347809,0.003692121,0.00008244166,0.001704898,0.00001122878],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988287,0.0005636416,0.0001301402,0.0000139296,0.000008897987,0.00001681338,0.0001328736,0.000002797197,0.0003022541],"genre_scores_gemma":[0.9984258,0.0003586366,0.000250117,0.00005817048,0.00003503644,0.00002447258,0.0003496264,0.000002382098,0.0004957667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003112639,"threshold_uncertainty_score":0.01041281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904536065774752,"score_gpt":0.2303086851450814,"score_spread":0.2112633244873339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}