{"id":"W4318816500","doi":"10.1038/s41392-023-01321-x","title":"Gonadotropin releasing hormone (GnRH): a hormone therapy boosts cognition in Down syndrome and dementia","year":2023,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Dementia; Hormone; Down syndrome; Gonadotropin-releasing hormone; Medicine; Gonadotropin; Endocrinology; Cognition; Hormone therapy; Internal medicine; Bioinformatics; Growth hormone; Biology; Luteinizing hormone; Psychiatry; Disease; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006800925,0.0005229338,0.0005158485,0.0005568855,0.000284398,0.0001884375,0.0001675424,0.0005368394,0.0002394396],"category_scores_gemma":[0.0000169642,0.000485334,0.0001433997,0.0005557338,0.0002495656,0.0002619989,0.00001678178,0.001186159,0.00002079167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003666785,"about_ca_system_score_gemma":0.00005602624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001365236,"about_ca_topic_score_gemma":0.000006650121,"domain_scores_codex":[0.9969205,0.0004796475,0.0005100872,0.0009826663,0.0005098679,0.0005972193],"domain_scores_gemma":[0.9992429,0.0002095699,0.0001849151,0.0002194946,0.00004051723,0.0001025718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002478042,0.0001358854,0.00005216414,0.00005506118,0.0001643178,0.001203821,0.000526058,0.000007194583,0.8987791,0.00002288288,0.01068486,0.08589061],"study_design_scores_gemma":[0.03506136,0.01043528,0.1851363,0.0009961518,0.0003468665,0.003906056,0.0004987888,0.001059138,0.1657906,0.009688479,0.5812581,0.005822795],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9040033,0.03308272,0.0002945432,0.06001353,0.0005322888,0.001413972,0.0002425375,0.0003410829,0.00007602987],"genre_scores_gemma":[0.6843782,0.2639143,0.00004326068,0.05032925,0.000533399,0.0001947293,0.0001468444,0.0001406116,0.000319357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7329885,"threshold_uncertainty_score":0.9997599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03659926269509402,"score_gpt":0.2549163106883393,"score_spread":0.2183170479932453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}