{"id":"W4318818788","doi":"10.1016/j.jaip.2023.01.028","title":"Long-Term Immune Reconstitution in ADA-Deficient Patients Treated With Elapegademase: A Real-World Experience","year":2023,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Stollery Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; Université de Montréal; University of Alberta; Children's Hospital of Eastern Ontario; University of Calgary","funders":"Janssen Pharmaceuticals; Takeda Canada; Hospital for Sick Children","keywords":"Medicine; Adverse effect; Adenosine deaminase; Enzyme replacement therapy; Immune system; Internal medicine; Gastroenterology; Dosing; Severe combined immunodeficiency; Immunology; Adenosine; Disease; In vivo; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004170716,0.0002606008,0.0003941084,0.000170258,0.0008248079,0.0007980855,0.0002087127,0.0007000023,0.0008562987],"category_scores_gemma":[0.0009620329,0.00009272966,0.0004179243,0.0002064388,0.0003668642,0.0003738054,0.0004226652,0.0007138393,0.0002390437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354429,"about_ca_system_score_gemma":0.0002400416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002913595,"about_ca_topic_score_gemma":0.000325755,"domain_scores_codex":[0.9998313,0.00005506688,0.00001694053,0.00002013789,0.00002108623,0.00005541258],"domain_scores_gemma":[0.9995982,0.00009843522,0.00005830504,0.00002630471,0.00002337085,0.0001954782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01277455,0.009567335,0.5336766,0.0004402775,0.000375513,0.1892543,0.007604985,0.001210524,0.02024294,0.001564103,0.003434091,0.2198547],"study_design_scores_gemma":[0.002245066,0.05018412,0.5336047,0.0003906931,0.0007204374,0.3668133,0.006847321,0.002217433,0.008746618,0.001422988,0.02662402,0.0001832478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960401,0.001798285,0.0003456332,0.0002895253,0.00002808415,0.00002222054,0.0000392466,0.00000661124,0.001430289],"genre_scores_gemma":[0.9983796,0.0007761884,0.0001562019,0.0002431805,0.00005715817,0.00001110946,0.00007258081,0.000004040252,0.0003000466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008562987,"threshold_uncertainty_score":0.002864659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03288376829380654,"score_gpt":0.3777488266473065,"score_spread":0.3448650583535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}