{"id":"W4318824159","doi":"10.1016/j.phrs.2023.106683","title":"Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer","year":2023,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire de Cardiologie et de Pneumologie de Québec","funders":"H2020 Marie Skłodowska-Curie Actions; GW Research; Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi; Jazz Pharmaceuticals","keywords":"VDAC1; Prostate cancer; Mitochondrion; Tramp; Cell biology; Cancer research; Voltage-dependent anion channel; Biology; Cancer cell; LNCaP; Carcinogenesis; Cannabidiol; Chemistry; Cancer; Biochemistry; Medicine; Bacterial outer membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001731937,0.0002538764,0.0004508407,0.0008507085,0.0002348994,0.00007779317,0.00027903,0.0002264918,0.0005429254],"category_scores_gemma":[0.0004080612,0.0001924354,0.0001154612,0.001866457,0.0005527036,0.000101031,0.0003983673,0.001654734,0.0001182356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005588667,"about_ca_system_score_gemma":0.0007489937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001436156,"about_ca_topic_score_gemma":0.00006792795,"domain_scores_codex":[0.9952853,0.0005127524,0.0004181579,0.0007667259,0.001422222,0.00159482],"domain_scores_gemma":[0.998239,0.0001826235,0.00004685344,0.0002390434,0.0004002073,0.000892212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002327339,0.000456036,0.006108906,0.0001755631,0.00004530267,0.001130552,0.0003913188,0.00006863733,0.7273457,0.00001962911,0.2416601,0.0202709],"study_design_scores_gemma":[0.01909949,0.005045572,0.284883,0.0001314989,0.0001306299,0.00003686117,0.0009642893,0.01231944,0.08900677,0.0005889824,0.5868522,0.0009413202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757713,0.003629894,0.000003059908,0.01726131,0.0002829253,0.001721143,0.00004707999,0.0001006018,0.001182667],"genre_scores_gemma":[0.9536011,0.02477937,0.00004436855,0.0003965379,0.0005149373,0.001214601,0.00003543573,0.00005073671,0.01936291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6383389,"threshold_uncertainty_score":0.7847287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975735700636517,"score_gpt":0.4338635543878559,"score_spread":0.3441061973814907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}