{"id":"W4318828366","doi":"10.3389/fimmu.2022.1047661","title":"After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Veterans Affairs Canada; University of Prince Edward Island; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Killam Trusts; Dalhousie University; Canadian Cancer Society; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute; Nova Scotia Health Research Foundation; National Institute of General Medical Sciences; Cancer Research Institute","keywords":"Bystander effect; NAD+ kinase; Metabolism; CD8; Virus; Chemistry; Virology; Cancer research; Biology; Biochemistry; Immunology; Immune system; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007907648,0.0002466857,0.0003025595,0.0001118038,0.0001517726,0.000342949,0.0001042922,0.0002787444,0.002578],"category_scores_gemma":[0.00009371694,0.0000686437,0.0002099221,0.00007222527,0.0001507984,0.0002617887,0.0001808238,0.0005185778,0.0006724951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802157,"about_ca_system_score_gemma":0.0001061699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001744986,"about_ca_topic_score_gemma":0.0003019178,"domain_scores_codex":[0.9999048,0.00001424335,0.00000604274,0.00003223275,0.00001919224,0.00002347433],"domain_scores_gemma":[0.999941,0.00001039785,0.00001285473,0.00001152038,0.00001143718,0.00001277591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001554059,0.00001608279,0.000502174,0.00005090397,0.000003508641,0.00008856551,0.00002800411,0.00002159821,0.9951509,0.00008758462,0.00005031711,0.003844913],"study_design_scores_gemma":[0.0000156906,0.0008829263,0.02011953,0.00002535758,0.00001542466,0.0008629315,0.0001845594,0.0004482551,0.9702753,0.0004148485,0.006746612,0.000008629282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844612,0.004972886,0.00570633,0.000139766,0.0001628811,0.00005712673,0.000373407,0.0001846831,0.003941636],"genre_scores_gemma":[0.9941941,0.0009268139,0.001435085,0.00006591455,0.00003276659,0.0000322514,0.0003170616,0.00001315137,0.00298296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002578,"threshold_uncertainty_score":0.008624256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591021973495098,"score_gpt":0.2691017124421206,"score_spread":0.2531914927071696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}