{"id":"W4318830010","doi":"10.1136/bmjopen-2022-064944","title":"Personalised azithromycin+metronidazole (PAZAZ), in combination with standard induction therapy, to achieve a faecal microbiome community structure and metagenome changes associated with sustained remission in paediatric Crohn’s disease (CD): protocol of a pilot study","year":2023,"lang":"en","type":"article","venue":"BMJ Open","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Health Canada; IWK Health Centre; Crohn's and Colitis Foundation; Crohn's and Colitis Foundation of America","keywords":"Medicine; Microbiome; Metronidazole; Internal medicine; Azithromycin; Crohn's disease; Disease; Randomized controlled trial; Antibiotics; Inflammatory bowel disease; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008501116,0.001743419,0.003187755,0.0008733884,0.001377389,0.001191241,0.002660768,0.002514534,0.01137397],"category_scores_gemma":[0.006344161,0.0010198,0.002089394,0.001000464,0.002064954,0.001033488,0.001347571,0.002488466,0.002378599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001694678,"about_ca_system_score_gemma":0.006634274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167957,"about_ca_topic_score_gemma":0.001829221,"domain_scores_codex":[0.9960799,0.002288929,0.0003509059,0.0004321758,0.0004304852,0.0004176633],"domain_scores_gemma":[0.9963319,0.0005740748,0.0007898773,0.0007575504,0.0005274159,0.001019271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8449083,0.09495985,0.002346055,0.002382913,0.0005202189,0.0002149994,0.000342725,0.001930645,0.01841796,0.000380511,0.001792014,0.03180381],"study_design_scores_gemma":[0.4427265,0.5404748,0.006662115,0.0001774953,0.0004102321,0.0001106232,0.00008081909,0.000388037,0.003370872,0.0002809212,0.005264405,0.00005319067],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3284588,0.0008611279,0.003836535,0.0005530879,0.0002880769,0.6607288,0.002793466,0.000108625,0.002371453],"genre_scores_gemma":[0.2164335,0.001013364,0.01145626,0.0007396594,0.000230465,0.7661977,0.001714026,0.00002343631,0.00219154],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01137397,"threshold_uncertainty_score":0.04495871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785883765323073,"score_gpt":0.3366030376998399,"score_spread":0.2987442000466092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}