{"id":"W4318912008","doi":"10.1007/s00005-023-00671-2","title":"Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne “Hologram” of Organ Function, Dysfunction and Cancer","year":2023,"lang":"en","type":"review","venue":"Archivum Immunologiae et Therapiae Experimentalis","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Microvesicles; Cancer; Extracellular vesicles; Computational biology; Liquid biopsy; Cancer cell; Disease; Biology; Stromal cell; Phenotype; Function (biology); Cancer research; Cell biology; Medicine; Pathology; microRNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006066376,0.000416516,0.0007383699,0.0001368203,0.00006637732,0.00002946161,0.0004110938,0.0002762036,0.0000114223],"category_scores_gemma":[0.00006648312,0.0003169283,0.0002519142,0.0002570287,0.000667084,0.00001204162,0.0003106254,0.0002489997,0.000001367436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000014186,"about_ca_system_score_gemma":0.00009617265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001418826,"about_ca_topic_score_gemma":0.00002030162,"domain_scores_codex":[0.9972637,0.0009154472,0.0007137673,0.0006031565,0.0001952278,0.000308684],"domain_scores_gemma":[0.9985948,0.0001061214,0.0004506373,0.0007618116,0.00003393237,0.00005271263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248971,0.0004167694,0.0003005803,0.001226866,0.000998672,0.00001948628,0.0004869414,0.000002914788,0.8034444,0.0004339511,0.0000219235,0.1925226],"study_design_scores_gemma":[0.002839663,0.002507108,0.002074475,0.003123664,0.001648893,0.0001409859,0.00175834,0.000007542528,0.9238587,0.001070849,0.05975862,0.001211155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3559267,0.6433055,0.00006019385,0.00002467651,0.00005883368,0.0005161181,0.00008495716,0.00001375721,0.000009249241],"genre_scores_gemma":[0.22946,0.7697798,0.0001357178,0.00004668393,0.00002588955,0.0002626657,0.0002122675,0.00006146696,0.00001548201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1913114,"threshold_uncertainty_score":0.9999283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03367351940736138,"score_gpt":0.3339194383373844,"score_spread":0.3002459189300231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}