{"id":"W4318913461","doi":"10.1371/journal.pone.0278087","title":"High dose rifampin for 2 months vs standard dose rifampin for 4 months, to treat TB infection: Protocol of a 3-arm randomized trial (2R2)","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; BC Centre for Disease Control; University of British Columbia; McGill University; University of Calgary; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Medicine; Tolerability; Discontinuation; Rifapentine; Internal medicine; Adverse effect; Rash; Randomized controlled trial; Tuberculosis; Regimen; Poisson regression; Population; Latent tuberculosis; Mycobacterium tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03077603,0.00680542,0.009907844,0.002022907,0.002782994,0.004118745,0.004573,0.007895289,0.06352734],"category_scores_gemma":[0.02452704,0.002743722,0.005460494,0.002902769,0.004324694,0.003550083,0.00221215,0.008440389,0.01275141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003501426,"about_ca_system_score_gemma":0.01088861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687235,"about_ca_topic_score_gemma":0.003337794,"domain_scores_codex":[0.9789548,0.01383198,0.001617368,0.001820285,0.001718352,0.002057279],"domain_scores_gemma":[0.988982,0.002949289,0.002436301,0.001802953,0.001847921,0.001981534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9728937,0.008928982,0.0003797153,0.003688418,0.00098357,0.00006943182,0.0001536028,0.0006795276,0.0009748341,0.001043688,0.004562712,0.005641886],"study_design_scores_gemma":[0.9719186,0.01880471,0.0005857808,0.0003050984,0.0003768549,0.00002604139,0.00003281453,0.0006432881,0.0002175268,0.0009294758,0.006126493,0.00003327849],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.007128084,0.0004153645,0.001375463,0.0004045252,0.0006523716,0.9866348,0.001786409,0.0001210751,0.001481857],"genre_scores_gemma":[0.008045496,0.0002726807,0.002798106,0.0004394914,0.0001930494,0.9864696,0.000540401,0.00001540793,0.001225731],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06352734,"threshold_uncertainty_score":0.2125201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08787929339741704,"score_gpt":0.3818466108437189,"score_spread":0.2939673174463019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}