{"id":"W4318915475","doi":"10.1093/nar/gkad023","title":"Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Chao Family Comprehensive Cancer Center; National Institutes of Health; National Cancer Institute; Ono Pharma Foundation; Ionis Pharmaceuticals","keywords":"Endosome; Oligonucleotide; Endocytic cycle; Biology; Small interfering RNA; Cell biology; Gene knockdown; Lysosome; Phospholipidosis; RNA interference; Endocytosis; RNA; Morpholino; Lipid bilayer fusion; Pharmacology; Biochemistry; DNA; Membrane; Cell; Apoptosis; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612317,0.0004212778,0.0003381878,0.0001610162,0.0001168992,0.0002934405,0.0001404123,0.0003087843,0.0007774046],"category_scores_gemma":[0.0001462908,0.0001674398,0.0002404142,0.0001174193,0.0002483428,0.0001751398,0.0002653203,0.0004101848,0.0003594107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002709001,"about_ca_system_score_gemma":0.0002123163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003396515,"about_ca_topic_score_gemma":0.0006957823,"domain_scores_codex":[0.9997912,0.00003830535,0.00002548503,0.00004743021,0.00005555809,0.00004202672],"domain_scores_gemma":[0.9999055,0.0000225418,0.00003585109,0.00001375886,0.00000895926,0.00001343949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001991319,0.000005893893,0.00003555296,0.0000135804,0.000002222749,0.00001153434,0.000003500692,0.00003143363,0.9992448,0.00004574377,0.000007721192,0.0005780403],"study_design_scores_gemma":[0.000005952874,0.000161662,0.0005878397,0.000002051707,0.000006062606,0.0001297901,0.000004232232,0.0002855338,0.9978278,0.00001955147,0.000967416,0.00000214747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829148,0.002340625,0.01170793,0.0001004416,0.00003476995,0.00007841846,0.0001671626,0.0002112813,0.002444417],"genre_scores_gemma":[0.9909928,0.001454722,0.005739953,0.00006063631,0.00001127756,0.00006849103,0.0001893935,0.0000282288,0.001454653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007774046,"threshold_uncertainty_score":0.00260067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764140926781423,"score_gpt":0.3343724393945111,"score_spread":0.2967310301266968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}