{"id":"W4318915475","doi":"10.1093/nar/gkad023","title":"Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Chao Family Comprehensive Cancer Center; National Institutes of Health; National Cancer Institute; Ono Pharma Foundation; Ionis Pharmaceuticals","keywords":"Endosome; Oligonucleotide; Endocytic cycle; Biology; Small interfering RNA; Cell biology; Gene knockdown; Lysosome; Phospholipidosis; RNA interference; Endocytosis; RNA; Morpholino; Lipid bilayer fusion; Pharmacology; Biochemistry; DNA; Membrane; Cell; Apoptosis; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003814124,0.0001017081,0.0001332545,0.0001575442,0.0001193459,0.00003877827,0.000083224,0.0001137791,0.00001022965],"category_scores_gemma":[0.0001208789,0.00009596588,0.00002733143,0.000213687,0.0001527321,0.000005221915,0.0003115653,0.0001249401,0.00005304947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001035809,"about_ca_system_score_gemma":0.00002853195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003951714,"about_ca_topic_score_gemma":0.00002013015,"domain_scores_codex":[0.9988787,0.0001122264,0.0001670271,0.0003126016,0.0002308259,0.0002986622],"domain_scores_gemma":[0.9993706,0.0001100189,0.00002594965,0.0002076622,0.0001909973,0.00009479994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406761,0.00001478759,0.0003828621,0.00003727122,0.00001992016,0.0000296067,0.0004013513,0.00006551848,0.9825235,0.00001231853,0.000356047,0.01601611],"study_design_scores_gemma":[0.0002802328,0.0007620934,0.0009784783,0.00006619087,0.000008133476,0.00001631986,0.001009573,0.002068211,0.9907527,0.0001061079,0.003831534,0.0001204158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989044,0.0002601431,0.00003410743,0.0001912255,0.00004360529,0.0001858671,0.00002315547,0.00001665427,0.000340841],"genre_scores_gemma":[0.996565,0.002331766,0.0002841513,0.000100409,0.0001025606,0.000005269525,0.00002535461,0.00002059491,0.0005648413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0158957,"threshold_uncertainty_score":0.3913375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764140926781423,"score_gpt":0.3343724393945111,"score_spread":0.2967310301266968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}