{"id":"W4318918491","doi":"10.1016/j.jdermsci.2023.01.008","title":"Cannabidiol mediates epidermal terminal differentiation and redox homeostasis through aryl hydrocarbon receptor (AhR)-dependent signaling","year":2023,"lang":"en","type":"article","venue":"Journal of Dermatological Science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nexen (Canada)","funders":"","keywords":"Cannabidiol; Aryl hydrocarbon receptor; Chemistry; Filaggrin; Cell biology; Involucrin; Pharmacology; Keratinocyte; Biochemistry; Biology; Immunology; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237842,0.0001649639,0.0004734067,0.0003324628,0.0002829728,0.0001204891,0.0002936441,0.0001115409,0.0001054765],"category_scores_gemma":[0.001052583,0.0001057507,0.0001317276,0.0009815784,0.0006353406,0.0004217749,0.0001769506,0.0004536769,0.00001684647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337811,"about_ca_system_score_gemma":0.0003515534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002041696,"about_ca_topic_score_gemma":0.000002400068,"domain_scores_codex":[0.9970232,0.00007727883,0.0006144607,0.0003088609,0.001402788,0.0005734671],"domain_scores_gemma":[0.9986708,0.00007290718,0.0003039934,0.0001561055,0.0003423324,0.0004538851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000678239,0.0004383998,0.1611055,0.0003685717,0.0001060279,0.003426355,0.002040497,0.00009709986,0.7772579,0.0004799796,0.02630288,0.02769856],"study_design_scores_gemma":[0.002787693,0.00131558,0.6660241,0.0004407207,0.0001525635,0.009956024,0.002041643,0.002958455,0.307506,0.002101437,0.004240005,0.0004757841],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794294,0.0008118817,0.00007951036,0.01903473,0.0002650271,0.0001795631,0.000006452871,0.00003435936,0.0001591105],"genre_scores_gemma":[0.9980917,0.0009445784,0.0002693075,0.0003328004,0.0001948626,0.000008282551,0.000004046336,0.000009408009,0.000145046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5049186,"threshold_uncertainty_score":0.4312388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809149927146719,"score_gpt":0.3156551934972651,"score_spread":0.2875636942257979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}