{"id":"W4318919263","doi":"10.1021/acs.est.2c06330","title":"Phosphorus Overload Promotes Hepatic Lipolysis by Suppressing GSK3β-Dependent Phosphorylation of PPARα at Ser84 and Thr265 in a Freshwater Teleost","year":2023,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Central University Basic Research Fund of China; Ministry of Science and Technology of the People's Republic of China","keywords":"Phosphorylation; Lipolysis; Peroxisome proliferator-activated receptor; GSK-3; Lipogenesis; Dephosphorylation; Internal medicine; Biology; Tyrosine phosphorylation; Chemistry; Serine; Endocrinology; Cell biology; Biochemistry; Lipid metabolism; Phosphatase; Adipose tissue; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009886826,0.0003057434,0.0002470583,0.0003236388,0.0003180778,0.0002355027,0.0001582312,0.000196597,0.002193884],"category_scores_gemma":[0.00007032538,0.0001633704,0.0005125966,0.0001918781,0.0003056886,0.0002238586,0.0002620276,0.0005095495,0.0002545019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319536,"about_ca_system_score_gemma":0.0004158722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432598,"about_ca_topic_score_gemma":0.00286351,"domain_scores_codex":[0.9999391,0.000004925116,0.000007565919,0.00001642007,0.00001435758,0.00001769828],"domain_scores_gemma":[0.9999665,0.00000265185,0.00001184657,0.00000275976,0.000003599269,0.00001271496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007002411,0.00004417706,0.0008044624,0.0001271702,0.00001380704,0.0001842452,0.00003172779,0.00009132529,0.9960338,0.00007672874,0.0001394092,0.001752931],"study_design_scores_gemma":[0.0004541064,0.002568753,0.08982686,0.00005250801,0.0002206649,0.001208453,0.0004572479,0.002769639,0.8922006,0.0005272833,0.00965574,0.00005811326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960459,0.00107859,0.0009949948,0.0002081826,0.00004751199,0.00001982195,0.0003671003,0.00006509193,0.001172892],"genre_scores_gemma":[0.994032,0.001079854,0.0008562722,0.0001222818,0.00002061152,0.00006635865,0.0005719592,0.00001902486,0.00323165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002193884,"threshold_uncertainty_score":0.007339299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003544815331247158,"score_gpt":0.2068895515090738,"score_spread":0.2033447361778266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}