{"id":"W4318919268","doi":"10.7554/elife.84051","title":"Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Vetenskapsrådet; Hjärt-Lungfonden; Cancerfonden; Key Project of Research and Development Plan of Hunan Province; Science Fund for Distinguished Young Scholars of Zhejiang Province; National Natural Science Foundation of China; Wellcome Trust","keywords":"Mendelian randomization; Alcohol consumption; Mendelian inheritance; Randomization; Medicine; Biology; Alcohol; Bioinformatics; Genetics; Computational biology; Gene; Clinical trial; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002990292,0.00009120329,0.0001631396,0.0001055611,0.0001025874,0.00001642203,0.00006128623,0.00006535699,0.00003803042],"category_scores_gemma":[0.0004578442,0.0000870534,0.00008648528,0.0002393006,0.00005165096,0.000001912728,0.00005699689,0.0000486787,0.00002412733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008077403,"about_ca_system_score_gemma":0.00002427008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001616149,"about_ca_topic_score_gemma":0.00002317212,"domain_scores_codex":[0.9991503,0.0001146933,0.0001943781,0.0002545564,0.00009104525,0.0001950247],"domain_scores_gemma":[0.9995558,0.00004168371,0.00008625549,0.000165318,0.00007658863,0.00007440029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002900749,0.000009431261,0.9634262,0.000004634534,0.0001976451,0.000002342979,0.00001371328,0.001374201,0.002646767,0.00002094217,0.03205783,0.0002173226],"study_design_scores_gemma":[0.001546301,0.00006685813,0.9812255,0.000005006832,0.0003503582,0.00001105909,0.0000511381,0.006501132,0.0003166844,0.00007881639,0.00970027,0.0001469071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859381,0.0002369982,0.01093116,0.00253895,0.00006063189,0.0001212364,0.0000456107,0.00003947056,0.00008780296],"genre_scores_gemma":[0.9952905,0.0003562203,0.0009502929,0.001810907,0.000157628,0.00002844336,0.000825559,0.000009921654,0.000570593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02235756,"threshold_uncertainty_score":0.3549935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0204225790654375,"score_gpt":0.2901735697863134,"score_spread":0.2697509907208759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}