{"id":"W4318919268","doi":"10.7554/elife.84051","title":"Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Vetenskapsrådet; Hjärt-Lungfonden; Cancerfonden; Key Project of Research and Development Plan of Hunan Province; Science Fund for Distinguished Young Scholars of Zhejiang Province; National Natural Science Foundation of China; Wellcome Trust","keywords":"Mendelian randomization; Alcohol consumption; Mendelian inheritance; Randomization; Medicine; Biology; Alcohol; Bioinformatics; Genetics; Computational biology; Gene; Clinical trial; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03393691,0.001434439,0.001855117,0.001652728,0.0007848914,0.0009017448,0.001499147,0.001273504,0.003697128],"category_scores_gemma":[0.06091885,0.0006946493,0.00305744,0.001656921,0.001132119,0.0006142893,0.0007930426,0.000897856,0.0002523385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009187541,"about_ca_system_score_gemma":0.001465681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003268105,"about_ca_topic_score_gemma":0.00217328,"domain_scores_codex":[0.9380397,0.05357061,0.001334528,0.004066624,0.002157497,0.0008311477],"domain_scores_gemma":[0.9622386,0.0265793,0.004647262,0.005375046,0.0007280093,0.0004318246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05188788,0.001632744,0.6597896,0.001481368,0.04408864,0.004299088,0.001106286,0.03077815,0.008397919,0.03899735,0.008253899,0.1492871],"study_design_scores_gemma":[0.02431889,0.01665659,0.3422442,0.0003961813,0.03358077,0.009041808,0.000360802,0.4824048,0.004944129,0.06886746,0.01668732,0.0004970561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7534443,0.003200246,0.2344296,0.001037879,0.0003310099,0.002917529,0.001766301,0.001015052,0.001858122],"genre_scores_gemma":[0.9044654,0.0005427236,0.09046984,0.0002904747,0.00009545861,0.002693226,0.0006065211,0.00007546201,0.0007609765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03393691,"threshold_uncertainty_score":0.1794777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0204225790654375,"score_gpt":0.2901735697863134,"score_spread":0.2697509907208759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}