{"id":"W4318920493","doi":"10.1002/jbmr.4778","title":"USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes","year":2020,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; McGill University Health Centre","funders":"Réseau de Recherche en Santé Buccodentaire et Osseuse; Shriners Hospitals for Children","keywords":"RANKL; Bone remodeling; Endocrinology; Osteoblast; Internal medicine; Osteoclast; Bone marrow; Cortical bone; Bone cell; Bone remodeling period; Adipose tissue; Chemistry; Parathyroid hormone; Cell biology; Biology; Receptor; Activator (genetics); Medicine; Anatomy; Calcium; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281357,0.0003355956,0.0002891413,0.0005120226,0.0002358404,0.000454375,0.0002477494,0.0003531296,0.001244569],"category_scores_gemma":[0.0001681862,0.0002526452,0.0003749238,0.0002189282,0.0004823529,0.0002479413,0.0003262152,0.0005467838,0.0004434481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003336527,"about_ca_system_score_gemma":0.0001878662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383294,"about_ca_topic_score_gemma":0.0005862935,"domain_scores_codex":[0.9996923,0.00003815049,0.00003244965,0.00006456449,0.0001092446,0.00006326723],"domain_scores_gemma":[0.9998071,0.00001697189,0.00007973109,0.00002047166,0.00002718206,0.0000486659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001196641,0.00001466126,0.0004850066,0.00004406824,0.000005841431,0.0001303769,0.00002414549,0.00003824259,0.9957505,0.0002954873,0.00007163494,0.003020298],"study_design_scores_gemma":[0.00004017886,0.0001779171,0.01234922,0.00001295077,0.00004162664,0.0007839217,0.00007675744,0.0008907564,0.9781224,0.0002727656,0.007218975,0.00001249365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773152,0.009570206,0.008351924,0.0002648053,0.00008074025,0.00004355236,0.0008318966,0.0004111296,0.003130544],"genre_scores_gemma":[0.9927908,0.00172142,0.002273092,0.00006108874,0.00001720522,0.00003243229,0.0004419551,0.00003432413,0.002627666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244569,"threshold_uncertainty_score":0.004163504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03097780910701721,"score_gpt":0.2975825615728976,"score_spread":0.2666047524658804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}