{"id":"W4318926335","doi":"10.1158/1078-0432.ccr-22-1989","title":"Biomarker Data from the Phase III KATHERINE Study of Adjuvant T-DM1 versus Trastuzumab for Residual Invasive Disease after Neoadjuvant Therapy for HER2-Positive Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Genentech; F. Hoffmann-La Roche","keywords":"Trastuzumab; Breast cancer; Medicine; Oncology; Adjuvant; Biomarker; Internal medicine; Adjuvant therapy; Neoadjuvant therapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006860819,0.0004215902,0.001155841,0.0002482201,0.0004099835,0.0001007186,0.001769411,0.0002267155,0.001654309],"category_scores_gemma":[0.003229537,0.0002818151,0.0003525116,0.001255099,0.00126218,0.0001620845,0.001131633,0.001159758,0.00004314274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005161459,"about_ca_system_score_gemma":0.004781779,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0112012,"about_ca_topic_score_gemma":0.00991831,"domain_scores_codex":[0.9918769,0.001270353,0.001361095,0.001807803,0.002277452,0.001406391],"domain_scores_gemma":[0.9801254,0.01414215,0.0002340886,0.002732961,0.001910946,0.0008544769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4026767,0.006880862,0.05064046,0.0003743514,0.002880605,0.0003335304,0.002304701,0.00001550149,0.001179689,0.00001168735,0.2701504,0.2625515],"study_design_scores_gemma":[0.1316573,0.01767987,0.7690491,0.001561432,0.0007944045,0.000003216784,0.007828035,0.003172722,0.0007825507,0.0003074768,0.06646869,0.0006952224],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251647,0.005192633,0.00002877383,0.01971531,0.0009298698,0.01122366,0.03762482,0.00007588407,0.00004432835],"genre_scores_gemma":[0.9731987,0.00893465,0.00005819276,0.0005020146,0.002834282,0.01163475,0.001755381,0.0001912115,0.0008908267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7184086,"threshold_uncertainty_score":0.9999634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5670680553339,"score_gpt":0.6237006534623429,"score_spread":0.0566325981284429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}