{"id":"W4318938722","doi":"10.1515/jpem-2022-0359","title":"An open-label extension of a phase 2 dose-finding study of once-weekly somatrogon vs. once-daily Genotropin in children with short stature due to growth hormone deficiency: results following 5 years of treatment","year":2023,"lang":"en","type":"article","venue":"Journal of Pediatric Endocrinology and Metabolism","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"OPKO Health (Canada)","funders":"OPKO Health; Pfizer","keywords":"Medicine; Adverse effect; Short stature; Growth hormone deficiency; Randomized controlled trial; Internal medicine; Pediatrics; Growth hormone; Animal science; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004808084,0.0002839542,0.001454136,0.001364274,0.00006617969,0.00001228041,0.0003075383,0.0001325481,0.000001155387],"category_scores_gemma":[0.0001981741,0.0002125582,0.0001052386,0.001332957,0.00006987077,0.0003117679,0.0001177222,0.0003952952,7.330138e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006114957,"about_ca_system_score_gemma":0.0003690577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004619658,"about_ca_topic_score_gemma":0.00002964185,"domain_scores_codex":[0.9971472,0.0001911934,0.001301999,0.0003956659,0.0004790694,0.0004848745],"domain_scores_gemma":[0.9983569,0.0001182534,0.0006786021,0.0003402814,0.000258854,0.0002470736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02263301,0.01727847,0.7356684,0.0001193849,0.001648017,0.002822592,0.01859774,0.0001634352,0.1704267,0.0001581416,0.0004754438,0.03000877],"study_design_scores_gemma":[0.0345978,0.02653516,0.9321821,0.00003990078,0.001498581,0.0002841736,0.001616413,0.0000128453,0.003003977,0.00002670174,0.00002765356,0.0001746967],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943391,0.004338975,0.00001639443,0.00009533963,0.0001752926,0.0009509976,0.00004910415,0.00001499232,0.00001976902],"genre_scores_gemma":[0.9938375,0.004542668,0.001311906,0.00002726722,0.0002037774,0.00001285703,0.00001759541,0.00003073402,0.00001563421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1965138,"threshold_uncertainty_score":0.8667873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03724245671405438,"score_gpt":0.3315595488455101,"score_spread":0.2943170921314557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}