{"id":"W4318940213","doi":"10.1016/j.ccell.2023.01.003","title":"IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment","year":2023,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Leukemia and Lymphoma Society of Canada; Weill Cornell Medical College; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Fondation ARC pour la Recherche sur le Cancer; Cancer Research Institute","keywords":"IDH2; Angioimmunoblastic T-cell lymphoma; Cancer research; Germinal center; Biology; Plasma cell; Epigenetics; Tumor microenvironment; Carcinogenesis; Mutation; B cell; Immunology; T cell; Cancer; Genetics; Gene; IDH1; Antibody; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000351362,0.0001111367,0.0001077671,0.00003270303,0.000107508,0.00002054597,0.00002458619,0.00002556357,0.0003077853],"category_scores_gemma":[0.00000148674,0.00006648,0.00004106026,0.0001139412,0.0000303834,0.00004471237,0.0000268577,0.00004416507,0.0001902634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002649196,"about_ca_system_score_gemma":0.00003706727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002627702,"about_ca_topic_score_gemma":0.00008405253,"domain_scores_codex":[0.9993824,0.00001352962,0.00008619577,0.0002228863,0.0001480681,0.0001469511],"domain_scores_gemma":[0.999656,0.00003855894,0.00003239106,0.0001562026,0.00002121556,0.00009562629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001690966,0.00262645,0.1303095,0.0004798985,0.001439255,0.0006878122,0.01105126,0.06933085,0.5733723,0.0001394434,0.1599477,0.04892463],"study_design_scores_gemma":[0.005904809,0.0007370061,0.4737381,0.0001759812,0.0008009339,0.00005236413,0.002913079,0.001483693,0.2823562,0.00002722889,0.2314539,0.0003568019],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924942,0.0009468439,0.00009646556,0.004628787,0.0001493261,0.0003921655,0.00001839341,0.00003205875,0.00124175],"genre_scores_gemma":[0.9922507,0.0005404777,0.00008780663,0.0008715331,0.00009849322,0.0003843545,0.00004869811,0.00001828646,0.005699644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3434286,"threshold_uncertainty_score":0.3370033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123094958287224,"score_gpt":0.2360064642402347,"score_spread":0.2236969684115123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}