{"id":"W4318940213","doi":"10.1016/j.ccell.2023.01.003","title":"IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment","year":2023,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Leukemia and Lymphoma Society of Canada; Weill Cornell Medical College; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Fondation ARC pour la Recherche sur le Cancer; Cancer Research Institute","keywords":"IDH2; Angioimmunoblastic T-cell lymphoma; Cancer research; Germinal center; Biology; Plasma cell; Epigenetics; Tumor microenvironment; Carcinogenesis; Mutation; B cell; Immunology; T cell; Cancer; Genetics; Gene; IDH1; Antibody; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102487,0.0003019221,0.0001901461,0.0002917631,0.0001077932,0.0002348036,0.000186877,0.0002427607,0.001500893],"category_scores_gemma":[0.0001033273,0.0001029683,0.0001562123,0.0001108388,0.000250895,0.0001976319,0.0002075573,0.0006062889,0.0001752424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318196,"about_ca_system_score_gemma":0.0001548072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003058401,"about_ca_topic_score_gemma":0.001015908,"domain_scores_codex":[0.9998117,0.00003715946,0.00001251912,0.00002493103,0.00005026774,0.0000633598],"domain_scores_gemma":[0.9999204,0.00001571376,0.0000144183,0.000008479267,0.000004295944,0.00003668736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002716217,0.0001984004,0.0005263214,0.00003146547,0.000009417457,0.0001037582,0.00001722476,0.0001289986,0.9961558,0.0001898708,0.0001200577,0.002247156],"study_design_scores_gemma":[0.0001456374,0.002414543,0.00641096,0.000006500287,0.00004824151,0.000686068,0.00005360558,0.001656905,0.9841908,0.0001126464,0.004265436,0.000008741421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960829,0.0006645739,0.001016665,0.0001066455,0.00004048752,0.00003445037,0.0001348884,0.00007777226,0.001841516],"genre_scores_gemma":[0.997858,0.0002237186,0.0005369705,0.00004855779,0.00001227801,0.00003282309,0.0001306198,0.000008541933,0.001148532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500893,"threshold_uncertainty_score":0.005021036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123094958287224,"score_gpt":0.2360064642402347,"score_spread":0.2236969684115123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}