{"id":"W4318956414","doi":"10.1016/j.jtho.2023.01.083","title":"Efficacy, Safety, and Health-Related Quality of Life With Camrelizumab Plus Pemetrexed and Carboplatin as First-Line Treatment for Advanced Nonsquamous NSCLC With Brain Metastases (CAP-BRAIN): A Multicenter, Open-Label, Single-Arm, Phase 2 Study","year":2023,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jiangsu Hengrui Medicine","keywords":"Medicine; Pemetrexed; Carboplatin; Internal medicine; Oncology; Response Evaluation Criteria in Solid Tumors; Clinical endpoint; Progression-free survival; Chemotherapy; Phases of clinical research; Surgery; Clinical trial; Cisplatin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003619879,0.001503727,0.001849233,0.0004620877,0.0003996186,0.000808891,0.0007639319,0.001080274,0.00167101],"category_scores_gemma":[0.001113613,0.0006385862,0.002032615,0.0004520925,0.0008340608,0.0008388482,0.0004156017,0.00179063,0.0002860544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008336814,"about_ca_system_score_gemma":0.001364661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005990449,"about_ca_topic_score_gemma":0.001128668,"domain_scores_codex":[0.9990265,0.000551472,0.00005265523,0.0001344678,0.0001006681,0.000134208],"domain_scores_gemma":[0.9990332,0.0001381165,0.0002557881,0.00007924852,0.00008455572,0.0004090913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.824486,0.07860097,0.03308139,0.0009144125,0.00358044,0.0001513801,0.0002220863,0.001368225,0.01249326,0.00009198523,0.001551945,0.04345786],"study_design_scores_gemma":[0.4977416,0.4414964,0.05309445,0.000032476,0.001999348,0.0001554986,0.00006088525,0.001823269,0.002297952,0.00009693758,0.001163622,0.00003763458],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973199,0.000865317,0.0001263242,0.00008173186,0.00002991237,0.0008709996,0.000361741,0.00001338784,0.0003307414],"genre_scores_gemma":[0.9957202,0.0005301457,0.0004208475,0.0003040268,0.0001374284,0.001417073,0.001017146,0.000004243896,0.0004488496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003619879,"threshold_uncertainty_score":0.019144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1298375190039732,"score_gpt":0.4863944786987144,"score_spread":0.3565569596947412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}