{"id":"W4318956414","doi":"10.1016/j.jtho.2023.01.083","title":"Efficacy, Safety, and Health-Related Quality of Life With Camrelizumab Plus Pemetrexed and Carboplatin as First-Line Treatment for Advanced Nonsquamous NSCLC With Brain Metastases (CAP-BRAIN): A Multicenter, Open-Label, Single-Arm, Phase 2 Study","year":2023,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jiangsu Hengrui Medicine","keywords":"Medicine; Pemetrexed; Carboplatin; Internal medicine; Oncology; Response Evaluation Criteria in Solid Tumors; Clinical endpoint; Progression-free survival; Chemotherapy; Phases of clinical research; Surgery; Clinical trial; Cisplatin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002712013,0.0004524259,0.002530254,0.0004174026,0.0002488973,0.00003811606,0.0001593577,0.0001142903,0.00003154044],"category_scores_gemma":[0.0009362721,0.000283521,0.0001184045,0.0005586755,0.00023134,0.0001611857,0.0001215797,0.0002747001,0.00000138746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006762091,"about_ca_system_score_gemma":0.001232239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112768,"about_ca_topic_score_gemma":0.002752638,"domain_scores_codex":[0.9959422,0.000886321,0.001719977,0.0005141962,0.0004497749,0.0004875379],"domain_scores_gemma":[0.9938285,0.002831862,0.001965845,0.0003775214,0.000383252,0.0006130721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4058883,0.06053844,0.002177528,0.0007293476,0.007073834,0.002615169,0.006386632,0.0008892812,0.0008798492,0.00005739601,0.0007408681,0.5120233],"study_design_scores_gemma":[0.4066119,0.5609452,0.01033204,0.000892844,0.003714368,0.001999505,0.009153521,0.001239149,0.0005867392,0.00004842574,0.003984177,0.0004922095],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680337,0.002970247,0.0004359626,0.02344163,0.0001181495,0.004688345,0.0002409387,0.00003282508,0.00003821195],"genre_scores_gemma":[0.9860563,0.000349946,0.01245346,0.0005708481,0.00005569259,0.00009823015,0.000118566,0.00006389802,0.0002330166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5115311,"threshold_uncertainty_score":0.9999617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1298375190039732,"score_gpt":0.4863944786987144,"score_spread":0.3565569596947412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}