{"id":"W4318976497","doi":"10.1038/s41522-023-00375-7","title":"Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence","year":2023,"lang":"en","type":"article","venue":"npj Biofilms and Microbiomes","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; McGill University Health Centre; Hospital for Sick Children; BioVectra (Canada); McGill University; University of Calgary; Université de Montréal; SickKids Foundation; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canada Research Chairs; Government of Canada; National Institute of General Medical Sciences; American Heart Association; Cystic Fibrosis Foundation","keywords":"Biofilm; Pseudomonas aeruginosa; Virulence; Microbiology; Polysaccharide; Glycoside hydrolase; Chemistry; Biology; Bacteria; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172504,0.0002706473,0.0002493407,0.000134249,0.0002448965,0.00007852018,0.0002013535,0.0002196523,0.000005815812],"category_scores_gemma":[0.00003282466,0.0002013721,0.0001024069,0.000419231,0.0003379736,0.00001573753,0.0003891909,0.0001004647,0.000004992821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007971741,"about_ca_system_score_gemma":0.00007497644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001173011,"about_ca_topic_score_gemma":0.00002091852,"domain_scores_codex":[0.9986148,0.00004502276,0.0003082461,0.0005132473,0.0001049331,0.0004136962],"domain_scores_gemma":[0.9992985,0.00001457467,0.0001842208,0.0003375152,0.00005909322,0.0001061059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005177348,0.00002143588,0.0004493965,0.00008152704,0.00003285886,0.000003326174,0.00008445299,5.883816e-7,0.9853343,0.00004054674,0.0006277444,0.01327209],"study_design_scores_gemma":[0.0004725385,0.000116845,0.001087485,0.00009139014,0.00003738691,0.0001000989,0.0001712906,0.0001274427,0.9904909,0.00002214026,0.0070109,0.0002715558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970949,0.001557989,0.00001468127,0.0005753516,0.0002978266,0.0002186584,0.0001584,0.00003952783,0.00004272149],"genre_scores_gemma":[0.997211,0.001254296,0.0006247844,0.0003328116,0.00009760103,0.000005295284,0.00005456948,0.00003245192,0.0003871997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01300054,"threshold_uncertainty_score":0.8211716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007801901679479232,"score_gpt":0.2187899364354284,"score_spread":0.2109880347559492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}