{"id":"W4318979117","doi":"10.1016/j.biopsych.2023.01.023","title":"Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome","year":2023,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"FP7 Health; FP7 People: Marie-Curie Actions; Weill Institute for Neurosciences, University of California, San Francisco; National Institute of Mental Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; European Regional Development Fund; Instituto de Salud Carlos III; National Institutes of Health; Dystonia Medical Research Foundation Canada; Manchester Biomedical Research Centre; Consejería de Salud y Bienestar Social, Junta de Andalucía; Ipsen; H. Lundbeck A/S; Emberi Eroforrások Minisztériuma; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Ministerio de Ciencia e Innovación; Magyar Tudományos Akadémia; Deutsche Forschungsgemeinschaft; National Science Foundation; Junta de Andalucía; Parkinson Canada; Tourette Association of America; Lundbeckfonden; Semmelweis Egyetem","keywords":"Genome-wide association study; Tourette syndrome; Locus (genetics); Genetic association; Biology; Genetic architecture; Genetics; Heritability; Neurodevelopmental disorder; Quantitative trait locus; Neuroscience; Gene; Single-nucleotide polymorphism; Psychology; Psychiatry; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043864,0.001126885,0.001742597,0.001790936,0.0002269773,0.0008776694,0.0009337857,0.001303267,0.002783776],"category_scores_gemma":[0.0005409613,0.0001784323,0.00068744,0.002047554,0.0004170823,0.0004348166,0.0005050434,0.001401482,0.0006356736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006023501,"about_ca_system_score_gemma":0.001067128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003109267,"about_ca_topic_score_gemma":0.006182009,"domain_scores_codex":[0.9998349,0.00002696002,0.00002287308,0.00004839968,0.00004939355,0.00001754241],"domain_scores_gemma":[0.9996908,0.0001762694,0.00004642245,0.000007336872,0.00004811985,0.00003097305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0003437112,0.00009251876,0.004424854,0.01317439,0.001211372,0.002470964,0.00006504648,0.0004108,0.002850798,0.001744733,0.02808058,0.9451302],"study_design_scores_gemma":[0.0004139308,0.0003035099,0.07160894,0.01310513,0.00562952,0.02434001,0.0004387654,0.0005376289,0.00144478,0.005535144,0.8764852,0.0001575446],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004696189,0.9982107,0.0001342683,0.0005150615,0.0001249943,0.000002622608,0.00005337637,0.000009112977,0.0004802706],"genre_scores_gemma":[0.003914251,0.9946752,0.000257081,0.0003892025,0.0002080139,0.000004687205,0.0001427513,0.000001943757,0.0004067759],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003109267,"threshold_uncertainty_score":0.00931263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05602269444916518,"score_gpt":0.3839640123558269,"score_spread":0.3279413179066618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}