{"id":"W4318981408","doi":"10.1038/s43587-022-00352-3","title":"Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy","year":2023,"lang":"en","type":"article","venue":"Nature Aging","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute on Deafness and Other Communication Disorders; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Autophagy; Stimulation; Neurogenesis; Hippocampal formation; Regulator; Environmental enrichment; Phenotype; Antidepressant; Neuroscience; Hippocampus; PI3K/AKT/mTOR pathway; Endocrinology; Biology; Signal transduction; Cell biology; Apoptosis; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370805,0.0004453755,0.0003339569,0.0004458782,0.0001153991,0.0001886422,0.0002089452,0.000367413,0.0008242041],"category_scores_gemma":[0.00008144139,0.0001693659,0.0002503089,0.0001205248,0.0002728275,0.000167037,0.0001307166,0.0006535645,0.0001974855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003194133,"about_ca_system_score_gemma":0.0002703296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009103029,"about_ca_topic_score_gemma":0.00283154,"domain_scores_codex":[0.9999112,0.00001265346,0.00001265776,0.00002188985,0.00001416005,0.00002747205],"domain_scores_gemma":[0.9998709,0.000007180877,0.00005190017,0.00001079414,0.000009696862,0.00004959519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005773432,0.0001403687,0.000402697,0.00004759986,0.00001127262,0.00004989246,0.00001373212,0.00006435804,0.9958497,0.00009992476,0.00009052037,0.002652593],"study_design_scores_gemma":[0.0002249496,0.002919758,0.02288739,0.00004077884,0.00008170244,0.000390404,0.00009348972,0.001451185,0.9672788,0.0002227121,0.004394115,0.00001475055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946972,0.001471803,0.001543487,0.0001750502,0.00005535826,0.00003658839,0.0009135834,0.0001913858,0.0009155778],"genre_scores_gemma":[0.9891503,0.001846809,0.003465692,0.0001762562,0.00002287444,0.00009931276,0.0009782254,0.0000396815,0.004220765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009103029,"threshold_uncertainty_score":0.002757251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902299307392265,"score_gpt":0.2723712151990031,"score_spread":0.2533482221250805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}