{"id":"W4318982566","doi":"10.3389/fcell.2023.1105565","title":"Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension","year":2023,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Southeastern Ontario Academic Medical Organization; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mitochondrial fission; Warburg effect; Mitochondrion; Biology; Pulmonary hypertension; Endocrinology; MFN1; DNM1L; Internal medicine; Mitochondrial biogenesis; Glycolysis; MFN2; Cell biology; mitochondrial fusion; Cancer research; Medicine; Biochemistry; Mitochondrial DNA; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441674,0.0003342515,0.0003229096,0.0006818131,0.0002601361,0.0003957953,0.0003394474,0.0007733277,0.001855389],"category_scores_gemma":[0.0004348585,0.0000941231,0.0002216726,0.0005170738,0.0004419804,0.000429523,0.0005417482,0.0007239342,0.0003639842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004719713,"about_ca_system_score_gemma":0.0003476645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006724442,"about_ca_topic_score_gemma":0.0007757395,"domain_scores_codex":[0.9998783,0.00003665634,0.00001753655,0.0000206788,0.00002485158,0.00002203062],"domain_scores_gemma":[0.999769,0.00004851711,0.00009006766,0.00001181615,0.00003653037,0.00004395345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003492072,0.0007629849,0.1049345,0.006882157,0.0006603903,0.1107297,0.001304373,0.002349205,0.2123335,0.06693834,0.02569349,0.4639194],"study_design_scores_gemma":[0.0003534429,0.001495137,0.2895982,0.001823568,0.0007667435,0.3980559,0.0008479198,0.005695357,0.03596757,0.05269751,0.212587,0.0001117516],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3047765,0.6521558,0.01330375,0.01181262,0.001059911,0.00009560932,0.0005826898,0.0002479111,0.01596518],"genre_scores_gemma":[0.8422271,0.1497898,0.002726514,0.0007954035,0.00101466,0.00004517446,0.0005337754,0.00001458699,0.002852878],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001855389,"threshold_uncertainty_score":0.00620693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727669609357653,"score_gpt":0.2828520604829737,"score_spread":0.2555753643893972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}