{"id":"W4318987669","doi":"10.1016/j.cell.2022.12.038","title":"Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre; Ontario Genomics","funders":"National Human Genome Research Institute; Center for Mendelian Genomics, University of Washington; Qatar National Research Fund; Federal Aviation Administration; National Institutes of Health; New South Wales Government; Fondation Bettencourt Schueller; Institut National de la Recherche Agronomique; Fonds National de la Recherche Luxembourg; Fonds de Recherche du Québec - Santé; Fondation Meyer pour le Développement Culturel et Artistique; Institut National de la Santé et de la Recherche Médicale; Sidra Medicine; Institut des maladies génétiques Imagine; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Fisher Center for Alzheimer's Research Foundation; Australian Government; Compute Canada; National Center for Advancing Translational Sciences; Calgary Foundation; Deutsche Forschungsgemeinschaft; McGill University; Fondation du Souffle; Meyer Foundation; European Molecular Biology Organization; Rockefeller University; European Commission; Sidaction; Immune Deficiency Foundation; JPB Foundation; Canadian Institutes of Health Research; Institut Curie; Center for Clinical and Translational Science, University of Illinois at Chicago; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Fundación Séneca; Agency for Science, Technology and Research; Yale University; St. Giles Foundation; National Health and Medical Research Council; SCOR Corporate Foundation for Science; Honjo International Scholarship Foundation; Glenn Foundation for Medical Research; Howard Hughes Medical Institute","keywords":"Biology; Immunity; IRF1; Immunology; Virology; Immune system; Microbiology; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002617332,0.0002077004,0.0002447608,0.0001308385,0.0005322601,0.00002913236,0.0005055084,0.0001876588,0.002166179],"category_scores_gemma":[0.00003170605,0.0002032556,0.0001223409,0.0004660985,0.0001226325,0.00007037009,0.0002708055,0.0003221987,0.02595393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003867819,"about_ca_system_score_gemma":0.00003416767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003316365,"about_ca_topic_score_gemma":0.000007202529,"domain_scores_codex":[0.9986567,0.0001331469,0.0002762852,0.0002975021,0.00003970213,0.0005966253],"domain_scores_gemma":[0.9992816,0.00004412727,0.00007347263,0.0005503991,0.0000379471,0.00001244429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002581457,0.000120761,0.0001218333,0.00002004282,0.00002684431,0.00000721312,0.001123564,0.00001633604,0.9889539,0.0001981815,0.007814109,0.001571387],"study_design_scores_gemma":[0.001587353,0.0002596493,0.1132424,0.00003249336,0.00003448512,0.00001261305,0.001909143,0.000003004601,0.4013625,0.0003088968,0.4807025,0.0005449848],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707932,0.002299592,0.00001297173,0.0001566197,0.001350872,0.0002106876,0.00004835677,0.0003121472,0.02481552],"genre_scores_gemma":[0.9448028,0.00003865083,0.00000515288,0.0002967714,0.000006815188,0.00002416533,0.0002551835,0.0000276295,0.05454288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5875914,"threshold_uncertainty_score":0.998746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194826768742367,"score_gpt":0.2430004321269128,"score_spread":0.2310521644394891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}