{"id":"W4318987669","doi":"10.1016/j.cell.2022.12.038","title":"Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre; Ontario Genomics","funders":"National Human Genome Research Institute; Center for Mendelian Genomics, University of Washington; Qatar National Research Fund; Federal Aviation Administration; National Institutes of Health; New South Wales Government; Fondation Bettencourt Schueller; Institut National de la Recherche Agronomique; Fonds National de la Recherche Luxembourg; Fonds de Recherche du Québec - Santé; Fondation Meyer pour le Développement Culturel et Artistique; Institut National de la Santé et de la Recherche Médicale; Sidra Medicine; Institut des maladies génétiques Imagine; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Fisher Center for Alzheimer's Research Foundation; Australian Government; Compute Canada; National Center for Advancing Translational Sciences; Calgary Foundation; Deutsche Forschungsgemeinschaft; McGill University; Fondation du Souffle; Meyer Foundation; European Molecular Biology Organization; Rockefeller University; European Commission; Sidaction; Immune Deficiency Foundation; JPB Foundation; Canadian Institutes of Health Research; Institut Curie; Center for Clinical and Translational Science, University of Illinois at Chicago; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Fundación Séneca; Agency for Science, Technology and Research; Yale University; St. Giles Foundation; National Health and Medical Research Council; SCOR Corporate Foundation for Science; Honjo International Scholarship Foundation; Glenn Foundation for Medical Research; Howard Hughes Medical Institute","keywords":"Biology; Immunity; IRF1; Immunology; Virology; Immune system; Microbiology; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633497,0.0002868237,0.0001425377,0.000140839,0.0001743873,0.0002253867,0.0001682148,0.0002302776,0.001247856],"category_scores_gemma":[0.0002057179,0.0001210411,0.0001333377,0.0000617246,0.0002403551,0.0001373472,0.0001796281,0.0002453098,0.0004639476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570844,"about_ca_system_score_gemma":0.0001557989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000414388,"about_ca_topic_score_gemma":0.0005253316,"domain_scores_codex":[0.9998747,0.00002127853,0.00001208588,0.00003039503,0.00002228057,0.00003923388],"domain_scores_gemma":[0.9998801,0.0000299819,0.00003426947,0.00002010558,0.00001069371,0.00002474296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457882,0.00001105965,0.00288824,0.00002264697,0.000003546307,0.0001986916,0.0000361055,0.00007766324,0.9950339,0.0001937753,0.00005139472,0.00133728],"study_design_scores_gemma":[0.00003140917,0.0002150201,0.0441035,0.00002265632,0.00002748899,0.004734288,0.0001592876,0.001101002,0.9465494,0.0002623622,0.00278316,0.0000105638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998044,0.0004717,0.0005520641,0.00002987981,0.000004792154,0.000004722986,0.0001982936,0.00001860835,0.0006758717],"genre_scores_gemma":[0.9989651,0.0001603351,0.0003579185,0.00001116836,0.000002306059,0.000004018736,0.0001886722,0.000005774047,0.0003046914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247856,"threshold_uncertainty_score":0.004174471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194826768742367,"score_gpt":0.2430004321269128,"score_spread":0.2310521644394891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}