{"id":"W4319006540","doi":"10.1161/str.54.suppl_1.wmp103","title":"Abstract WMP103: Proteome-wide Mendelian Randomization Screen Identifies Circulating Protein Mediators Of Early-onset Ischemic Stroke","year":2023,"lang":"en","type":"article","venue":"Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University","funders":"","keywords":"Medicine; Mendelian randomization; Stroke (engine); Internal medicine; Genome-wide association study; Cardiology; Single-nucleotide polymorphism; Genetic variants; Genetics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0108466,0.001558447,0.001591122,0.001590799,0.0007625864,0.001229132,0.001142453,0.001112754,0.005838214],"category_scores_gemma":[0.01933041,0.0004090795,0.003076831,0.002973778,0.0007421821,0.0005155059,0.0008115384,0.0008221462,0.0004912101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649883,"about_ca_system_score_gemma":0.001259282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002336788,"about_ca_topic_score_gemma":0.00209103,"domain_scores_codex":[0.9905634,0.005604686,0.0006379709,0.001999195,0.0008355288,0.0003590949],"domain_scores_gemma":[0.9929173,0.003989465,0.001638759,0.0008816129,0.000322154,0.0002506549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03587989,0.001034287,0.7229567,0.002685647,0.04901251,0.006046961,0.0004731393,0.0076966,0.06635715,0.004854048,0.01595084,0.0870522],"study_design_scores_gemma":[0.01105271,0.008886691,0.8370274,0.0003699761,0.05518675,0.007418975,0.0002716485,0.02699196,0.02350808,0.008887301,0.02015888,0.0002397267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9009661,0.004605954,0.06572928,0.001553956,0.0002716015,0.0008867902,0.02165199,0.001432255,0.002902091],"genre_scores_gemma":[0.9719702,0.0005030642,0.0204341,0.0005179928,0.0001157939,0.0007243269,0.004792593,0.0001241422,0.0008178898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0108466,"threshold_uncertainty_score":0.05736297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01530322463890283,"score_gpt":0.2622161706484939,"score_spread":0.2469129460095911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}