{"id":"W4319019656","doi":"10.3390/membranes13020182","title":"Membrane-Based Hybrid Method for Purifying PEGylated Proteins","year":2023,"lang":"en","type":"article","venue":"Membranes","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Polyethylene glycol; Microfiltration; Chromatography; Membrane; PEG ratio; Micelle; Chemistry; Materials science; Lyotropic; Salt (chemistry); Chemical engineering; Polymer; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003484224,0.0005545528,0.0004295488,0.0006123865,0.0003196562,0.0004291109,0.0005728634,0.0007107113,0.001200214],"category_scores_gemma":[0.0002307471,0.0002172217,0.0004510623,0.0003994994,0.0001965341,0.0006169293,0.0006332521,0.0009463248,0.00133565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003068489,"about_ca_system_score_gemma":0.0001704209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003745431,"about_ca_topic_score_gemma":0.0005018457,"domain_scores_codex":[0.9996301,0.00003974274,0.00002942039,0.0001029833,0.0001689481,0.00002877836],"domain_scores_gemma":[0.9998794,0.00002218484,0.00002456596,0.00002072316,0.0000385254,0.00001471283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002503353,0.00002773277,0.0001257672,0.00009057239,0.00002011193,0.00003597804,0.00002139641,0.0001076609,0.9907934,0.0002443856,0.0002010817,0.008306984],"study_design_scores_gemma":[0.000009012248,0.0001032421,0.0009028549,0.00001121281,0.00003583438,0.0004062871,0.00001513748,0.004352925,0.9817888,0.0001309675,0.01222103,0.0000225893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3130669,0.006892376,0.6707093,0.0004334372,0.0003153996,0.0005772319,0.0008913142,0.00265871,0.004455315],"genre_scores_gemma":[0.5163266,0.005708949,0.458234,0.0005017194,0.0001266854,0.000971249,0.002682432,0.0002494802,0.01519879],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001200214,"threshold_uncertainty_score":0.004015148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02613021135251634,"score_gpt":0.3081071083703212,"score_spread":0.2819768970178048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}