{"id":"W4319027073","doi":"10.1016/j.cell.2023.01.039","title":"Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic","year":2023,"lang":"en","type":"review","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; European Commission; University of Alberta; European Federation of Pharmaceutical Industries and Associations; Österreichischen Akademie der Wissenschaften; Heart and Stroke Foundation of Canada","keywords":"Biology; Angiotensin-converting enzyme 2; Pandemic; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Tropism; 2019-20 coronavirus outbreak; Coronavirus; Receptor; Viral entry; Peptidyl-Dipeptidase A; Enzyme; Virus; Viral replication; Infectious disease (medical specialty); Genetics; Biochemistry; Disease; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003729222,0.0004506698,0.0008305902,0.001142378,0.0002329159,0.0008787447,0.0005062816,0.0008821859,0.003879772],"category_scores_gemma":[0.000494331,0.0001537395,0.0003222761,0.0009863207,0.0003195641,0.001037724,0.0005140258,0.001792071,0.002449148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004307611,"about_ca_system_score_gemma":0.0008234293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007940888,"about_ca_topic_score_gemma":0.001571013,"domain_scores_codex":[0.9998983,0.00002188255,0.00001128958,0.00001662693,0.0000374161,0.00001443685],"domain_scores_gemma":[0.9998468,0.00005776115,0.00001839616,0.000004842434,0.00004823332,0.00002390577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001235513,0.00005672258,0.0001741446,0.009174773,0.00007393865,0.0002386448,0.00007961752,0.0002036431,0.001371085,0.007944168,0.0687442,0.9118155],"study_design_scores_gemma":[0.00001446784,0.0000502624,0.0003754818,0.002010889,0.00004575418,0.0006578233,0.00004298219,0.00003665008,0.00018135,0.001856093,0.9947203,0.00000797816],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000110375,0.9975673,0.00006434674,0.000695036,0.0002840005,0.000002798058,0.00001951524,0.000006656567,0.001249864],"genre_scores_gemma":[0.0009411199,0.9972636,0.0001032157,0.0004788298,0.0002894047,0.000004434495,0.00003139878,0.000001532871,0.000886543],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003879772,"threshold_uncertainty_score":0.01297915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1860789952793647,"score_gpt":0.4186428631559539,"score_spread":0.2325638678765893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}