{"id":"W4319027073","doi":"10.1016/j.cell.2023.01.039","title":"Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic","year":2023,"lang":"en","type":"review","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; European Commission; University of Alberta; European Federation of Pharmaceutical Industries and Associations; Österreichischen Akademie der Wissenschaften; Heart and Stroke Foundation of Canada","keywords":"Biology; Angiotensin-converting enzyme 2; Pandemic; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Tropism; 2019-20 coronavirus outbreak; Coronavirus; Receptor; Viral entry; Peptidyl-Dipeptidase A; Enzyme; Virus; Viral replication; Infectious disease (medical specialty); Genetics; Biochemistry; Disease; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001259885,0.0003254272,0.001256608,0.0001454485,0.0002027273,0.00001843469,0.0005540199,0.000349619,0.00005893331],"category_scores_gemma":[0.00101013,0.000157533,0.001017734,0.0008256581,0.0003154155,0.00001629163,0.0005430287,0.0008626558,0.000945603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004469694,"about_ca_system_score_gemma":0.001946073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712673,"about_ca_topic_score_gemma":0.00005613152,"domain_scores_codex":[0.9974548,0.0003650463,0.000623266,0.0004490361,0.0006262696,0.000481649],"domain_scores_gemma":[0.9968303,0.001490097,0.0002887744,0.00121492,0.00009454758,0.00008138119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002335878,0.0003714779,0.01094575,0.2153007,0.001432884,0.0005073089,0.002001375,0.000001577743,0.01243381,0.00006188173,0.48934,0.2673697],"study_design_scores_gemma":[0.0003383464,0.00003925514,0.00001684348,0.002354649,0.0005314426,0.000208,0.00003570752,0.000008472193,0.001443809,0.00001972626,0.9948532,0.0001505331],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007705378,0.9948873,0.00000383197,0.0007186797,0.0003573555,0.001413213,0.00002870648,0.00009114159,0.001729267],"genre_scores_gemma":[0.000171552,0.9288626,0.000008145328,0.06368601,0.000615192,0.0001069174,0.00001897114,0.000155526,0.006375086],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5055132,"threshold_uncertainty_score":0.9998323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1860789952793647,"score_gpt":0.4186428631559539,"score_spread":0.2325638678765893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}