{"id":"W4319058179","doi":"10.1210/clinem/dgad058","title":"Efficacy and Safety of Fezolinetant in Moderate to Severe Vasomotor Symptoms Associated With Menopause: A Phase 3 RCT","year":2023,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Astellas Pharma US","keywords":"Placebo; Medicine; Vasomotor; Context (archaeology); Menopause; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00237466,0.0002528653,0.001750831,0.0003112983,0.00008323722,0.000008351032,0.000203292,0.0001355884,0.00005119488],"category_scores_gemma":[0.002330917,0.0001334511,0.00004695581,0.0005465235,0.0002178206,0.00008747667,0.00008855027,0.0008312683,0.00001420479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004231296,"about_ca_system_score_gemma":0.0003951261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004468575,"about_ca_topic_score_gemma":0.0000275668,"domain_scores_codex":[0.9959678,0.0007723465,0.001968873,0.000224826,0.0004404091,0.0006257242],"domain_scores_gemma":[0.9959023,0.001987133,0.000940949,0.0003557511,0.0002849285,0.000528956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5695522,0.02112997,0.07032876,0.0006090552,0.02144603,0.01128027,0.007760219,0.00308223,0.0284781,0.002288438,0.005259332,0.2587854],"study_design_scores_gemma":[0.1480924,0.02266786,0.8155293,0.0008002886,0.002922341,0.001562307,0.0001084354,0.0003817175,0.0007486762,0.0004202555,0.006498682,0.0002676547],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989257,0.001628282,0.00002772527,0.007886068,0.0002945742,0.0007437466,0.00003304565,0.00002474952,0.0001047532],"genre_scores_gemma":[0.9941026,0.003695828,0.0002269164,0.001404585,0.000241801,0.000006737237,0.000006986778,0.00003230708,0.0002822658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7452006,"threshold_uncertainty_score":0.5441977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06620361840714238,"score_gpt":0.41537047846098,"score_spread":0.3491668600538376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}