{"id":"W4319058179","doi":"10.1210/clinem/dgad058","title":"Efficacy and Safety of Fezolinetant in Moderate to Severe Vasomotor Symptoms Associated With Menopause: A Phase 3 RCT","year":2023,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Astellas Pharma US","keywords":"Placebo; Medicine; Vasomotor; Context (archaeology); Menopause; Internal medicine; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004287249,0.0009565769,0.002061138,0.0003344389,0.0005068069,0.001006347,0.0006286558,0.001963862,0.005984226],"category_scores_gemma":[0.004173349,0.0005186739,0.003321757,0.0003907266,0.0006190747,0.0007865045,0.0003598548,0.002034754,0.0005835833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006696162,"about_ca_system_score_gemma":0.001451123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120794,"about_ca_topic_score_gemma":0.002822077,"domain_scores_codex":[0.9984779,0.001032983,0.0001338377,0.0001203427,0.000114866,0.0001201162],"domain_scores_gemma":[0.9979898,0.0008835254,0.0005976165,0.0001393759,0.0001689077,0.0002207853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9311439,0.008759942,0.002077118,0.009240272,0.005342555,0.0001461339,0.0003258558,0.00037141,0.006177109,0.0001539864,0.001522733,0.03473898],"study_design_scores_gemma":[0.8898606,0.0972061,0.006390687,0.0004639262,0.002942954,0.00009899665,0.0000870531,0.0002898692,0.0005891881,0.0001792215,0.001869811,0.00002170389],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947117,0.02347143,0.00155458,0.001238966,0.0005644735,0.01963723,0.002115654,0.0001489211,0.004151649],"genre_scores_gemma":[0.9747093,0.006969314,0.002602657,0.001314713,0.0003161794,0.01145403,0.0006579638,0.00002362245,0.001952338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005984226,"threshold_uncertainty_score":0.02267337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06620361840714238,"score_gpt":0.41537047846098,"score_spread":0.3491668600538376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}