{"id":"W4319059273","doi":"10.1080/14737159.2023.2176753","title":"How reliable are polygenic risk scores for risk prediction in patients with heart disease?","year":2023,"lang":"en","type":"editorial","venue":"Expert Review of Molecular Diagnostics","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Polygenic risk score; Disease; Framingham Risk Score; Medicine; Internal medicine; Biology; Genetics; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01715858,0.003033533,0.005793703,0.002718918,0.001199755,0.004357915,0.003088748,0.01159728,0.003908822],"category_scores_gemma":[0.0429948,0.001214091,0.002635139,0.001197881,0.002010399,0.003430809,0.001304274,0.01957808,0.003311558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002166184,"about_ca_system_score_gemma":0.00278375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001829835,"about_ca_topic_score_gemma":0.004138232,"domain_scores_codex":[0.9947378,0.001879861,0.001001216,0.0006648605,0.001544983,0.0001712979],"domain_scores_gemma":[0.9596072,0.02714924,0.001310532,0.0007099779,0.009765312,0.001457684],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002184865,0.00002135756,0.0001704762,0.0014304,0.0003574454,0.0001132074,0.00002838282,0.000042429,0.00009061011,0.0006820344,0.9648306,0.03201461],"study_design_scores_gemma":[0.001015955,0.0001708661,0.002008135,0.006882379,0.001635005,0.0006727962,0.000127566,0.0008002299,0.0002967197,0.005477244,0.9807967,0.000116466],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0001140867,0.09201424,0.000555028,0.08708907,0.8191878,0.00003585297,0.0001355019,0.00007485275,0.0007935974],"genre_scores_gemma":[0.001038041,0.0450599,0.0005371115,0.05330727,0.897298,0.00005835922,0.00007147431,0.00004371579,0.002586047],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.9828414,"threshold_uncertainty_score":0.09074432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005721560381645779,"score_gpt":0.2607384818280829,"score_spread":0.2550169214464371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}