{"id":"W4319063659","doi":"10.1093/brain/awad018","title":"Memantine: a novel treatment for children with developmental and epileptic encephalopathies","year":2023,"lang":"en","type":"letter","venue":"Brain","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University","funders":"","keywords":"Memantine; Psychology; Encephalopathy; Randomized controlled trial; Medicine; Placebo; Pediatrics; Epilepsy; Crossover study; Neuroscience; Psychiatry; Dementia; Internal medicine; Disease; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001280918,0.0004007726,0.0005718179,0.0002319273,0.0001277017,0.00004481552,0.00007422817,0.0002563603,0.00004230816],"category_scores_gemma":[0.0001076865,0.000257115,0.0001143074,0.0001525862,0.0001463314,0.00003521896,0.00004654418,0.0003285789,0.00007308256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089654,"about_ca_system_score_gemma":0.0004123776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000128666,"about_ca_topic_score_gemma":0.00009052983,"domain_scores_codex":[0.9982467,0.00002492872,0.0002191872,0.0005790325,0.0003665052,0.0005636505],"domain_scores_gemma":[0.9991348,0.000359843,0.00007332432,0.0002274055,0.0000589292,0.0001456812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003914865,0.0003022265,0.03116005,0.0004271543,0.002170917,0.001598687,0.0004461758,1.557686e-7,0.0001917465,0.00002347611,0.9484648,0.0148231],"study_design_scores_gemma":[0.02826756,0.01202999,0.2913958,0.001673361,0.001242814,0.004450241,0.0002406265,0.00003180018,0.0009223957,0.0001191336,0.6584253,0.001200984],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1424545,0.0006408796,0.0001856449,0.8485004,0.0001113387,0.006070738,0.001034185,0.0002924461,0.0007098614],"genre_scores_gemma":[0.05222846,0.001820012,0.05184298,0.6472824,0.01098699,0.01094959,0.02866545,0.001111539,0.1951126],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2900395,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673917251046365,"score_gpt":0.294612388034344,"score_spread":0.2578732155238803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}