{"id":"W4319063659","doi":"10.1093/brain/awad018","title":"Memantine: a novel treatment for children with developmental and epileptic encephalopathies","year":2023,"lang":"en","type":"letter","venue":"Brain","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University","funders":"","keywords":"Memantine; Psychology; Encephalopathy; Randomized controlled trial; Medicine; Placebo; Pediatrics; Epilepsy; Crossover study; Neuroscience; Psychiatry; Dementia; Internal medicine; Disease; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003369929,0.0008404544,0.001514039,0.0007397682,0.002335511,0.00193611,0.001777604,0.03082774,0.005374018],"category_scores_gemma":[0.02001965,0.0004930724,0.001451869,0.0007475031,0.002185356,0.002801732,0.0008024846,0.02769507,0.005892792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003158948,"about_ca_system_score_gemma":0.003260295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00422621,"about_ca_topic_score_gemma":0.008392346,"domain_scores_codex":[0.9972357,0.00100966,0.0004224218,0.0003242508,0.0007900787,0.0002179923],"domain_scores_gemma":[0.9910344,0.006020898,0.0005908873,0.0001630969,0.001440154,0.0007505387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002024958,0.00002679508,0.0001517655,0.0001273022,0.00002000062,0.0006663226,0.00004784717,0.00003459221,0.0001859085,0.001352145,0.9817362,0.01544859],"study_design_scores_gemma":[0.0009009116,0.0002868656,0.001350812,0.0009307395,0.00009727484,0.002590626,0.0001654458,0.0003012479,0.0004576317,0.007396823,0.9854605,0.00006126955],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003366132,0.006594807,0.00008542367,0.9567154,0.03400306,0.00001107121,0.000126271,0.00002728037,0.002100142],"genre_scores_gemma":[0.002664928,0.00394459,0.0002052067,0.9066171,0.08242049,0.00004027572,0.00005952059,0.00002301759,0.004024865],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03082774,"threshold_uncertainty_score":0.02291983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673917251046365,"score_gpt":0.294612388034344,"score_spread":0.2578732155238803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}