{"id":"W4319066240","doi":"10.1016/j.jaad.2023.01.029","title":"Trajectories and prognosis after discontinuation of biologics due to remission in psoriasis: A nationwide cohort study","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Sanofi Genzyme; LEO Pharma; Bausch Health; Simon Spies Fonden; LEO Fondet; Coloplast; Mylan; Horizon Therapeutics; UCB Pharma; Kongelig Hofbuntmager Aage Bangs Fond; Regeneron Pharmaceuticals; Sanofi; Galderma; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Pfizer; Samsung; National Psoriasis Foundation; Amgen","keywords":"Medicine; Discontinuation; Psoriasis; Cohort study; Cohort; Dermatology; MEDLINE; Internal medicine; Pediatrics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003138542,0.000253547,0.0006800288,0.001269281,0.0004639958,0.001087038,0.000750103,0.0009271823,0.002007833],"category_scores_gemma":[0.01289264,0.0004413087,0.001293988,0.003754934,0.0002543135,0.0008129738,0.0009589393,0.001054268,0.0003003368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005827511,"about_ca_system_score_gemma":0.0007427647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0166809,"about_ca_topic_score_gemma":0.01552621,"domain_scores_codex":[0.9972862,0.0009298215,0.0005246867,0.0006292791,0.0003599875,0.0002700335],"domain_scores_gemma":[0.9900492,0.002878513,0.004302981,0.001106134,0.001105802,0.0005572976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004679449,0.00006651411,0.9890692,0.0003156475,0.001403426,0.000152607,0.0002594906,0.00009984428,0.00008047687,0.0001300027,0.003321646,0.004633211],"study_design_scores_gemma":[0.00004532584,0.00008845295,0.9962046,0.0002494358,0.0006872476,0.000244696,0.000225739,0.0003667118,0.00002442081,0.000101253,0.001742525,0.0000196756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710333,0.01239649,0.0004005273,0.001602415,0.0001371632,0.00005503872,0.01351418,0.00001559029,0.0008452447],"genre_scores_gemma":[0.9897823,0.002473321,0.0003813591,0.0003128015,0.0001077107,0.00005432099,0.006695936,0.00001117629,0.0001809643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0166809,"threshold_uncertainty_score":0.0331676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652792258692802,"score_gpt":0.2864238922055715,"score_spread":0.2698959696186435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}